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Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood

Bhargava, Santosh K., Sachdev, Harshpal Singh, Fall, Caroline H.D., Osmond, Clive, Lakshmy, Ramakrishnan, Barker, David J.P., Biswas, Sushant K. Dey, Ramji, Siddharth, Prabhakaran, Dorairaj and Reddy, Kolli Srinath (2004) Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood New England Journal of Medicine, 350, (9), pp. 865-875.

Record type: Article


Background: The risk of type 2 diabetes mellitus is increased in people who have low birth weights and who subsequently become obese as adults. Whether their obesity originates in childhood and, if so, at what age are unknown. Understanding the origin of obesity may be especially important in developing countries, where type 2 diabetes is rapidly increasing yet public health messages still focus on reducing childhood "undernutrition."
Methods: We evaluated glucose tolerance and plasma insulin concentrations in 1492 men and women 26 to 32 years of age who had been measured at birth and at intervals of three to six months throughout infancy, childhood, and adolescence in a prospective, population-based study.
Results: The prevalence of impaired glucose tolerance was 10.8 percent, and that of diabetes was 4.4 percent. Subjects with impaired glucose tolerance or diabetes typically had a low body-mass index up to the age of two years, followed by an early adiposity rebound (the age after infancy when body mass starts to rise) and an accelerated increase in body-mass index until adulthood. However, despite an increase in body-mass index between the ages of 2 and 12 years, none of these subjects were obese at the age of 12 years. The odds ratio for disease associated with an increase in the body-mass index of 1 SD from 2 to 12 years of age was 1.36 (95 percent confidence interval, 1.18 to 1.57; P<0.001).
Conclusions: There is an association between thinness in infancy and the presence of impaired glucose tolerance or diabetes in young adulthood. Crossing into higher categories of body-mass index after the age of two years is also associated with these disorders.

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Published date: 26 February 2004


Local EPrints ID: 25260
PURE UUID: 4add16e3-3859-431a-98d6-4a780d1749c2
ORCID for Clive Osmond: ORCID iD

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Date deposited: 06 Apr 2006
Last modified: 30 Sep 2017 10:09

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Author: Santosh K. Bhargava
Author: Harshpal Singh Sachdev
Author: Clive Osmond ORCID iD
Author: Ramakrishnan Lakshmy
Author: David J.P. Barker
Author: Sushant K. Dey Biswas
Author: Siddharth Ramji
Author: Dorairaj Prabhakaran
Author: Kolli Srinath Reddy

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