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Lifelong exposure to dietary fish oil alters macrophage responses in Walker 256 tumor-bearing rats

Lifelong exposure to dietary fish oil alters macrophage responses in Walker 256 tumor-bearing rats
Lifelong exposure to dietary fish oil alters macrophage responses in Walker 256 tumor-bearing rats
Supplementation of the diet with fish oil (FO) decreases growth of the Walker 256 tumor and decreases the cachexia associated with tumor-bearing. The mechanisms by which FO inhibits tumor growth and cachexia are unknown. Macrophages are very important in host defence against tumors since they produce several anti-tumor agents which in turn have been shown to be modified by dietary FO, but rarely in the setting of tumor bearing and never in relation to lifelong exposure. In this study, we compared the effects of supplementation of the diet of pregnant and lactating rats and subsequent supplementation of the offspring with coconut fat or FO on macrophage activities involved in anti-tumor defence. FO supplementation was able to induce an increase in phagocytosis, in O•2-, H2O2, nitric oxide, and TNF-? production by macrophages and in lysosomal volume in non-tumor-bearing rats. However, phagocytosis, production of O•2- and H2O2 and lysosomal volume were not affected by the FO diet when rats were bearing tumors, although nitric oxide production was higher in these animals. It appears that tumor bearing activates the innate immune system and that dietary FO has little effect on innate immunity in the presence of Walker 256 tumors. Thus, it is still unclear how FO decreases the growth of Walker 256 tumors and the associated cachexia.
walker 256 tumor, macrophages, fish oil, supplementation, immune response
0008-8749
56-62
Bonatto, Sandro J.R.
582fcf10-3f71-411b-a90a-404bfbffaa0a
Folador, Alessandra
d2069067-ed26-4ae6-a0cc-45f8291397f9
Aikawa, Júlia
71a53c59-ac50-4f93-b8d0-aa0c55799092
Yamazaki, Ricardo K.
dc3167fd-8a53-4bc1-b099-113334382bd1
Pizatto, Nathalia
4680684b-4f90-4882-9b17-3e39410b5640
Oliveira, Heloisa H.P.
09df4ebf-4d5b-4d85-9a90-9283dcfaf1e0
Vecchi, Rodrigo
7758e615-7901-4bd2-8da6-8c38cd775ef9
Curi, Rui
87abee54-a75d-4e94-b9b9-2169d8f97fec
Calder, Phillip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Fernandes, Luiz C.
380a7161-4e23-40d3-afde-7cc36ec65060
Bonatto, Sandro J.R.
582fcf10-3f71-411b-a90a-404bfbffaa0a
Folador, Alessandra
d2069067-ed26-4ae6-a0cc-45f8291397f9
Aikawa, Júlia
71a53c59-ac50-4f93-b8d0-aa0c55799092
Yamazaki, Ricardo K.
dc3167fd-8a53-4bc1-b099-113334382bd1
Pizatto, Nathalia
4680684b-4f90-4882-9b17-3e39410b5640
Oliveira, Heloisa H.P.
09df4ebf-4d5b-4d85-9a90-9283dcfaf1e0
Vecchi, Rodrigo
7758e615-7901-4bd2-8da6-8c38cd775ef9
Curi, Rui
87abee54-a75d-4e94-b9b9-2169d8f97fec
Calder, Phillip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Fernandes, Luiz C.
380a7161-4e23-40d3-afde-7cc36ec65060

Bonatto, Sandro J.R., Folador, Alessandra, Aikawa, Júlia, Yamazaki, Ricardo K., Pizatto, Nathalia, Oliveira, Heloisa H.P., Vecchi, Rodrigo, Curi, Rui, Calder, Phillip and Fernandes, Luiz C. (2004) Lifelong exposure to dietary fish oil alters macrophage responses in Walker 256 tumor-bearing rats. Cellular Immunology, 231 (1-2), 56-62. (doi:10.1016/j.cellimm.2004.12.001).

Record type: Article

Abstract

Supplementation of the diet with fish oil (FO) decreases growth of the Walker 256 tumor and decreases the cachexia associated with tumor-bearing. The mechanisms by which FO inhibits tumor growth and cachexia are unknown. Macrophages are very important in host defence against tumors since they produce several anti-tumor agents which in turn have been shown to be modified by dietary FO, but rarely in the setting of tumor bearing and never in relation to lifelong exposure. In this study, we compared the effects of supplementation of the diet of pregnant and lactating rats and subsequent supplementation of the offspring with coconut fat or FO on macrophage activities involved in anti-tumor defence. FO supplementation was able to induce an increase in phagocytosis, in O•2-, H2O2, nitric oxide, and TNF-? production by macrophages and in lysosomal volume in non-tumor-bearing rats. However, phagocytosis, production of O•2- and H2O2 and lysosomal volume were not affected by the FO diet when rats were bearing tumors, although nitric oxide production was higher in these animals. It appears that tumor bearing activates the innate immune system and that dietary FO has little effect on innate immunity in the presence of Walker 256 tumors. Thus, it is still unclear how FO decreases the growth of Walker 256 tumors and the associated cachexia.

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Published date: 2004
Keywords: walker 256 tumor, macrophages, fish oil, supplementation, immune response

Identifiers

Local EPrints ID: 25268
URI: http://eprints.soton.ac.uk/id/eprint/25268
ISSN: 0008-8749
PURE UUID: 029cbbe6-beac-417c-aa75-899b90550a93
ORCID for Phillip Calder: ORCID iD orcid.org/0000-0002-6038-710X

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Date deposited: 06 Apr 2006
Last modified: 11 Mar 2021 02:35

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Contributors

Author: Sandro J.R. Bonatto
Author: Alessandra Folador
Author: Júlia Aikawa
Author: Ricardo K. Yamazaki
Author: Nathalia Pizatto
Author: Heloisa H.P. Oliveira
Author: Rodrigo Vecchi
Author: Rui Curi
Author: Phillip Calder ORCID iD
Author: Luiz C. Fernandes

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