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The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study

Boyne, Michael S., Thame, Minerva, Bennett, Franklyn I., Osmond, Clive, Miell, John P. and Forrester, Terrence E. (2003) The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study Journal of Clinical Endocrinology and Metabolism, 88, (4), pp. 1687-1691.

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Fetal IGF-I is a determinant of birth weight, but whether maternal IGF-I plays a significant role is controversial. We sought to examine the relationships among maternal IGF-I, IGF-binding protein (IGFBP)-1, and IGFBP-2, with maternal and newborn anthropometry, in a cohort of 325 nondiabetic pregnant women of African origin. Blood was collected for IGF-I, IGFBP-1, and IGFBP-2 at 9, 25, and 35 wk gestation and in cord blood at delivery.
In the second and third trimesters, maternal IGF-I was significantly correlated (P < 0.005) with maternal body mass index and triceps skinfold thickness. Maternal IGFBP-1 and -2 had an inverse correlation (P < 0.0001), with maternal anthropometry. Maternal IGF-I at 35 wk, and fetal IGF-I by cord blood were significantly correlated with birth weight (P = 0.001 and 0.048, respectively). IGFBP-1 in the third trimester and cord blood were negatively correlated with birth weight (P = 0.012 and 0.002). In multiple regression analyses, maternal IGF-I at 35 wk, fetal IGF-I, maternal weight at the first antenatal visit, gender, and gestational age were significant independent factors in the determination of birth weight. In conclusion, maternal IGF-I levels, especially during late pregnancy, positively influence birth weight.

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Published date: 2003


Local EPrints ID: 25276
ISSN: 0021-972X
PURE UUID: 71595dfa-5abb-4050-90d7-07ce66509764
ORCID for Clive Osmond: ORCID iD

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Date deposited: 06 Apr 2006
Last modified: 17 Jul 2017 16:11

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Author: Michael S. Boyne
Author: Minerva Thame
Author: Franklyn I. Bennett
Author: Clive Osmond ORCID iD
Author: John P. Miell
Author: Terrence E. Forrester

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