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The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study

The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study
The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study
Fetal IGF-I is a determinant of birth weight, but whether maternal IGF-I plays a significant role is controversial. We sought to examine the relationships among maternal IGF-I, IGF-binding protein (IGFBP)-1, and IGFBP-2, with maternal and newborn anthropometry, in a cohort of 325 nondiabetic pregnant women of African origin. Blood was collected for IGF-I, IGFBP-1, and IGFBP-2 at 9, 25, and 35 wk gestation and in cord blood at delivery.
In the second and third trimesters, maternal IGF-I was significantly correlated (P < 0.005) with maternal body mass index and triceps skinfold thickness. Maternal IGFBP-1 and -2 had an inverse correlation (P < 0.0001), with maternal anthropometry. Maternal IGF-I at 35 wk, and fetal IGF-I by cord blood were significantly correlated with birth weight (P = 0.001 and 0.048, respectively). IGFBP-1 in the third trimester and cord blood were negatively correlated with birth weight (P = 0.012 and 0.002). In multiple regression analyses, maternal IGF-I at 35 wk, fetal IGF-I, maternal weight at the first antenatal visit, gender, and gestational age were significant independent factors in the determination of birth weight. In conclusion, maternal IGF-I levels, especially during late pregnancy, positively influence birth weight.
0021-972X
1687-1691
Boyne, Michael S.
7d787822-30fc-42e4-b3d4-8d3df98dfabd
Thame, Minerva
92fe8177-22ab-4730-9f30-7e1988ac427b
Bennett, Franklyn I.
749d6b69-bc4f-4a84-98b1-1cfcb4c9dfe6
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Miell, John P.
117a7477-ff62-4d7c-aa0f-8217c0362b47
Forrester, Terrence E.
d5ed0294-0713-4521-baf9-923f1cae5e7f
Boyne, Michael S.
7d787822-30fc-42e4-b3d4-8d3df98dfabd
Thame, Minerva
92fe8177-22ab-4730-9f30-7e1988ac427b
Bennett, Franklyn I.
749d6b69-bc4f-4a84-98b1-1cfcb4c9dfe6
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Miell, John P.
117a7477-ff62-4d7c-aa0f-8217c0362b47
Forrester, Terrence E.
d5ed0294-0713-4521-baf9-923f1cae5e7f

Boyne, Michael S., Thame, Minerva, Bennett, Franklyn I., Osmond, Clive, Miell, John P. and Forrester, Terrence E. (2003) The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study. Journal of Clinical Endocrinology & Metabolism, 88 (4), 1687-1691.

Record type: Article

Abstract

Fetal IGF-I is a determinant of birth weight, but whether maternal IGF-I plays a significant role is controversial. We sought to examine the relationships among maternal IGF-I, IGF-binding protein (IGFBP)-1, and IGFBP-2, with maternal and newborn anthropometry, in a cohort of 325 nondiabetic pregnant women of African origin. Blood was collected for IGF-I, IGFBP-1, and IGFBP-2 at 9, 25, and 35 wk gestation and in cord blood at delivery.
In the second and third trimesters, maternal IGF-I was significantly correlated (P < 0.005) with maternal body mass index and triceps skinfold thickness. Maternal IGFBP-1 and -2 had an inverse correlation (P < 0.0001), with maternal anthropometry. Maternal IGF-I at 35 wk, and fetal IGF-I by cord blood were significantly correlated with birth weight (P = 0.001 and 0.048, respectively). IGFBP-1 in the third trimester and cord blood were negatively correlated with birth weight (P = 0.012 and 0.002). In multiple regression analyses, maternal IGF-I at 35 wk, fetal IGF-I, maternal weight at the first antenatal visit, gender, and gestational age were significant independent factors in the determination of birth weight. In conclusion, maternal IGF-I levels, especially during late pregnancy, positively influence birth weight.

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Published date: 2003

Identifiers

Local EPrints ID: 25276
URI: https://eprints.soton.ac.uk/id/eprint/25276
ISSN: 0021-972X
PURE UUID: 71595dfa-5abb-4050-90d7-07ce66509764
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 06 Apr 2006
Last modified: 16 Jul 2019 01:08

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