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Mechanisms underlying the programming of small artery dysfunction: review of the model using low protein diet in pregnancy in the rat

Mechanisms underlying the programming of small artery dysfunction: review of the model using low protein diet in pregnancy in the rat
Mechanisms underlying the programming of small artery dysfunction: review of the model using low protein diet in pregnancy in the rat
Human and animal studies have shown that unbalanced maternal nutrition is associated with the development of cardiovascular and metabolic disease in adulthood. In the Southampton maternal low protein model (SMLP), protein deprivation (50%) throughout pregnancy in rats leads to elevated blood pressure in adult offspring. Impaired peripheral arterial function may contribute to the cardiovascular dysfunction observed in these offspring. This review discusses the impact of such a dietary insult on the vascular function of resistance arteries from pregnant rats (pF 0 ), their offspring (F 1 ), the pregnant offspring (pF 1 ) and the second generation (F 2 ). At each stage, disturbances in endothelium-dependent relaxation were observed, implicating changes in endothelial nitric oxide (NO)-guanylate cyclase (GC) signalling pathway in the vascular adaptations to pregnancy and the programmed effects on offspring.
vascular, low protein, nitric oxide, programming, pregnancy, vascular endothelial growth factor, mesenteric, uterine, thoracic aorta, transgenerational.
1381-3455
23-35
Brawley, L.
efe37d09-41fb-4f0e-9f50-5e018e0d46ae
Poston, L.
7503d11e-bc6a-4925-b622-bf2937ab1722
Hanson, M. A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Brawley, L.
efe37d09-41fb-4f0e-9f50-5e018e0d46ae
Poston, L.
7503d11e-bc6a-4925-b622-bf2937ab1722
Hanson, M. A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Brawley, L., Poston, L. and Hanson, M. A. (2003) Mechanisms underlying the programming of small artery dysfunction: review of the model using low protein diet in pregnancy in the rat. Archives of Physiology and Biochemistry, 111 (1), 23-35. (doi:10.1076/apab.111.1.23.15138).

Record type: Article

Abstract

Human and animal studies have shown that unbalanced maternal nutrition is associated with the development of cardiovascular and metabolic disease in adulthood. In the Southampton maternal low protein model (SMLP), protein deprivation (50%) throughout pregnancy in rats leads to elevated blood pressure in adult offspring. Impaired peripheral arterial function may contribute to the cardiovascular dysfunction observed in these offspring. This review discusses the impact of such a dietary insult on the vascular function of resistance arteries from pregnant rats (pF 0 ), their offspring (F 1 ), the pregnant offspring (pF 1 ) and the second generation (F 2 ). At each stage, disturbances in endothelium-dependent relaxation were observed, implicating changes in endothelial nitric oxide (NO)-guanylate cyclase (GC) signalling pathway in the vascular adaptations to pregnancy and the programmed effects on offspring.

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More information

Published date: 2003
Keywords: vascular, low protein, nitric oxide, programming, pregnancy, vascular endothelial growth factor, mesenteric, uterine, thoracic aorta, transgenerational.

Identifiers

Local EPrints ID: 25278
URI: https://eprints.soton.ac.uk/id/eprint/25278
ISSN: 1381-3455
PURE UUID: 1ab869cf-641d-420b-8021-51c5308678ec
ORCID for M. A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 15 Aug 2019 00:48

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