The University of Southampton
University of Southampton Institutional Repository

Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy

Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy
Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy
Protein restriction in rat pregnancy programmes the development of elevated systolic blood pressure and vascular dysfunction in the offspring.
A recent study has shown that hypertension is reversed by maternal glycine supplementation. Whether this protective effect is exerted directly on the embryo and fetus, or indirectly via effects on the mother, is unknown although we have previously shown abnormalities in the maternal vasculature. We tested the hypothesis that dietary glycine repletion would reverse endothelial dysfunction in protein-restricted pregnant rat dams using wire myography. Impaired acetylcholine- (P < 0.01) and isoprenaline-induced (P < 0.05) vasodilatation in isolated mesenteric arteries (MA) from protein-restricted pregnant dams was accompanied by reduced vascular nitric oxide (NO) release (P < 0.05). Dietary glycine supplementation reversed vascular dysfunction in MA (P < 0.05) and improved NO release thus potentially protecting the maternal circulation. The impaired NO release in the MA of low protein diet dams was not accompanied by reduced eNOS mRNA expression, suggesting that eNOS activity was altered. Protein restriction did not alter the vascular function of a conduit artery, the thoracic aorta.
These results provide evidence that adequate provision of glycine, a conditionally essential amino acid in pregnancy, may play a role in the vascular adaptations to pregnancy, protecting the fetus from abnormal programming of the cardiovascular system.
0022-3751
497-504
Brawley, L.
efe37d09-41fb-4f0e-9f50-5e018e0d46ae
Torrens, C.
15a35713-0651-4249-8227-5901e2cfcd22
Anthony, F.W.
398b8bed-237e-4fad-a77d-89266fb00bc0
Itoh, S.
9fd6c457-bc53-4512-a5c3-86dc10f9cb52
Wheeler, T.
6aefc7d2-5cf8-4a45-8295-144cf78a7edb
Jackson, A.A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494
Poston, L.
7503d11e-bc6a-4925-b622-bf2937ab1722
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Brawley, L.
efe37d09-41fb-4f0e-9f50-5e018e0d46ae
Torrens, C.
15a35713-0651-4249-8227-5901e2cfcd22
Anthony, F.W.
398b8bed-237e-4fad-a77d-89266fb00bc0
Itoh, S.
9fd6c457-bc53-4512-a5c3-86dc10f9cb52
Wheeler, T.
6aefc7d2-5cf8-4a45-8295-144cf78a7edb
Jackson, A.A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Clough, G.F.
9f19639e-a929-4976-ac35-259f9011c494
Poston, L.
7503d11e-bc6a-4925-b622-bf2937ab1722
Hanson, M.A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Brawley, L., Torrens, C., Anthony, F.W., Itoh, S., Wheeler, T., Jackson, A.A., Clough, G.F., Poston, L. and Hanson, M.A. (2004) Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy. The Journal of Physiology, 554 (2), 497-504. (doi:10.1113/jphysiol.2003.052068).

Record type: Article

Abstract

Protein restriction in rat pregnancy programmes the development of elevated systolic blood pressure and vascular dysfunction in the offspring.
A recent study has shown that hypertension is reversed by maternal glycine supplementation. Whether this protective effect is exerted directly on the embryo and fetus, or indirectly via effects on the mother, is unknown although we have previously shown abnormalities in the maternal vasculature. We tested the hypothesis that dietary glycine repletion would reverse endothelial dysfunction in protein-restricted pregnant rat dams using wire myography. Impaired acetylcholine- (P < 0.01) and isoprenaline-induced (P < 0.05) vasodilatation in isolated mesenteric arteries (MA) from protein-restricted pregnant dams was accompanied by reduced vascular nitric oxide (NO) release (P < 0.05). Dietary glycine supplementation reversed vascular dysfunction in MA (P < 0.05) and improved NO release thus potentially protecting the maternal circulation. The impaired NO release in the MA of low protein diet dams was not accompanied by reduced eNOS mRNA expression, suggesting that eNOS activity was altered. Protein restriction did not alter the vascular function of a conduit artery, the thoracic aorta.
These results provide evidence that adequate provision of glycine, a conditionally essential amino acid in pregnancy, may play a role in the vascular adaptations to pregnancy, protecting the fetus from abnormal programming of the cardiovascular system.

Full text not available from this repository.

More information

Published date: 2004
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 25279
URI: https://eprints.soton.ac.uk/id/eprint/25279
ISSN: 0022-3751
PURE UUID: 2a530786-4824-498f-af35-da305f796b47
ORCID for G.F. Clough: ORCID iD orcid.org/0000-0002-6226-8964
ORCID for M.A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 11 Apr 2006
Last modified: 27 Jul 2018 00:34

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×