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Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1ß -511 single nucleotide polymorphism

Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1ß -511 single nucleotide polymorphism
Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1ß -511 single nucleotide polymorphism
Background: Cachexia is common in chronic obstructive pulmonary disease (COPD) and is thought to be linked to an enhanced systemic inflammatory response.
Objective: We investigated differences in the systemic inflammatory profile and polymorphisms in related inflammatory genes in COPD patients.
Design: A cross-sectional study was performed in 99 patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stages II–IV), who were stratified by cachexia based on fat-free mass index (FFMI; in kg/m2: <16 for men and <15 for women) and compared with healthy control subjects (HCs). Body composition was determined by bioelectrical impedance analysis. Plasma concentrations and gene polymorphisms of interleukin 1ß (IL-1ß –511), IL-6 (IL-6 –174), and the tumor necrosis factor system (TNF- –308 and lymphotoxin- +252) were determined. Plasma C-reactive protein, leptin, and urinary pseudouridine (as a marker of cellular protein breakdown) were measured.
Results: Fat mass, leptin, and pseudouridine were significantly different (P < 0.001) between noncachectic patients (NCPs) and cachectic patients (CPs: n = 35); the systemic inflammatory cytokine profile was not. NCPs had a body compositional shift toward a lower fat-free mass and a higher fat mass compared with HCs. CPs and NCPs had a greater systemic inflammatory response (P < 0.05) than did HCs, as reflected in C-reactive protein, soluble TNF-R75, and IL-6 concentrations. The overall distribution of the IL-1ß –511 polymorphism was significantly different between the groups (P < 0.05).
Conclusions: In COPD patients, who are characterized by an elevated systemic inflammatory response, cachexia is not discriminatory for the extent of increase in inflammatory status. This study, however, indicates a potential influence of genetic predisposition on the cachexia process.
chronic obstructive pulmonary disease, copd, body composition, inflammation, polymorphism, cachexia, protein breakdown, leptin
0002-9165
1059-1064
Broekhuizen, Roelinka
69733129-7910-4516-a070-c30a0bbc3a6e
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Howell, W. Martin
ecbb0dd6-f904-4da2-a05d-e542862531f8
Shale, Dennis J.
1cb59300-0c34-48e9-9eba-4065164b45a4
Creutzberg, Eva C.
c040b3ec-75fe-4b29-bd8f-71ea11a84910
Wouters, Emiel F.
86a4ce43-d197-46bb-bf3d-dd644b84d33f
Schols, Annemie M.
4320334d-f74b-4fe4-a26d-7357be6830d2
Broekhuizen, Roelinka
69733129-7910-4516-a070-c30a0bbc3a6e
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Howell, W. Martin
ecbb0dd6-f904-4da2-a05d-e542862531f8
Shale, Dennis J.
1cb59300-0c34-48e9-9eba-4065164b45a4
Creutzberg, Eva C.
c040b3ec-75fe-4b29-bd8f-71ea11a84910
Wouters, Emiel F.
86a4ce43-d197-46bb-bf3d-dd644b84d33f
Schols, Annemie M.
4320334d-f74b-4fe4-a26d-7357be6830d2

Broekhuizen, Roelinka, Grimble, Robert F., Howell, W. Martin, Shale, Dennis J., Creutzberg, Eva C., Wouters, Emiel F. and Schols, Annemie M. (2005) Pulmonary cachexia, systemic inflammatory profile, and the interleukin 1ß -511 single nucleotide polymorphism. American Journal of Clinical Nutrition, 82 (5), 1059-1064.

Record type: Article

Abstract

Background: Cachexia is common in chronic obstructive pulmonary disease (COPD) and is thought to be linked to an enhanced systemic inflammatory response.
Objective: We investigated differences in the systemic inflammatory profile and polymorphisms in related inflammatory genes in COPD patients.
Design: A cross-sectional study was performed in 99 patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stages II–IV), who were stratified by cachexia based on fat-free mass index (FFMI; in kg/m2: <16 for men and <15 for women) and compared with healthy control subjects (HCs). Body composition was determined by bioelectrical impedance analysis. Plasma concentrations and gene polymorphisms of interleukin 1ß (IL-1ß –511), IL-6 (IL-6 –174), and the tumor necrosis factor system (TNF- –308 and lymphotoxin- +252) were determined. Plasma C-reactive protein, leptin, and urinary pseudouridine (as a marker of cellular protein breakdown) were measured.
Results: Fat mass, leptin, and pseudouridine were significantly different (P < 0.001) between noncachectic patients (NCPs) and cachectic patients (CPs: n = 35); the systemic inflammatory cytokine profile was not. NCPs had a body compositional shift toward a lower fat-free mass and a higher fat mass compared with HCs. CPs and NCPs had a greater systemic inflammatory response (P < 0.05) than did HCs, as reflected in C-reactive protein, soluble TNF-R75, and IL-6 concentrations. The overall distribution of the IL-1ß –511 polymorphism was significantly different between the groups (P < 0.05).
Conclusions: In COPD patients, who are characterized by an elevated systemic inflammatory response, cachexia is not discriminatory for the extent of increase in inflammatory status. This study, however, indicates a potential influence of genetic predisposition on the cachexia process.

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More information

Published date: November 2005
Additional Information: Original research communication
Keywords: chronic obstructive pulmonary disease, copd, body composition, inflammation, polymorphism, cachexia, protein breakdown, leptin

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Local EPrints ID: 25280
URI: http://eprints.soton.ac.uk/id/eprint/25280
ISSN: 0002-9165
PURE UUID: 597a34e7-bc1d-4dc4-927d-30d328a42a1a

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Date deposited: 10 Apr 2006
Last modified: 22 Jul 2020 16:46

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