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Vitamin A for acute respiratory infection in developing countries: a meta-analysis

Vitamin A for acute respiratory infection in developing countries: a meta-analysis
Vitamin A for acute respiratory infection in developing countries: a meta-analysis
Aim: To determine the efficacy of intervention with high-dose vitamin A as an adjunct to standard treatment on outcome in acute lower respiratory tract infection in children in developing countries. Methods: A systematic review of double-blinded, randomized, controlled intervention studies of high-dose vitamin A or placebo in children aged between 1?mo and 6?y presenting with acute non-measles lower respiratory tract infection. Results: Five studies fulfilling the criteria were identified and included a total of 2177 children (1067 intervention, 1110 control). The main outcome measures were time to normalization of fever, respiratory rate and oxygen dependence, time to discharge, and mortality. On meta-analysis, there were no significant differences in any of the recovery measures or mortality between the intervention and control groups. Pooled results for recovery times are given showing difference in days to recovery days and 95% confidence intervals. Positive summary measures indicate faster recovery in the vitamin A group and negative in the placebo: fever: 0.03 (?0.10 to 0.17); oxygen requirement: ?0.08 (?0.31 to 0.16); raised respiratory rate: ?0.09 (?0.38 to 0.19); hospital stay: ?0.06 (?0.52 to 0.40). Mortality was below 2% in both groups, with a non-significantly higher risk in the intervention group (odds ratio 1.16, 95% CI: 0.61-2.21).
acute lower respiratory tract infection, children, meta-analysis, randomized controlled trial, vitamin a
0803-5253
1437-1442
Brown, N.
8e202102-bb2a-4257-aef6-e07737a68a92
Roberts, C.
b1dc377a-04e8-4757-9e1c-faaf8361ed7a
Brown, N.
8e202102-bb2a-4257-aef6-e07737a68a92
Roberts, C.
b1dc377a-04e8-4757-9e1c-faaf8361ed7a

Brown, N. and Roberts, C. (2004) Vitamin A for acute respiratory infection in developing countries: a meta-analysis. Acta Paediatrica, 93 (11), 1437-1442. (doi:10.1080/08035250410022143).

Record type: Article

Abstract

Aim: To determine the efficacy of intervention with high-dose vitamin A as an adjunct to standard treatment on outcome in acute lower respiratory tract infection in children in developing countries. Methods: A systematic review of double-blinded, randomized, controlled intervention studies of high-dose vitamin A or placebo in children aged between 1?mo and 6?y presenting with acute non-measles lower respiratory tract infection. Results: Five studies fulfilling the criteria were identified and included a total of 2177 children (1067 intervention, 1110 control). The main outcome measures were time to normalization of fever, respiratory rate and oxygen dependence, time to discharge, and mortality. On meta-analysis, there were no significant differences in any of the recovery measures or mortality between the intervention and control groups. Pooled results for recovery times are given showing difference in days to recovery days and 95% confidence intervals. Positive summary measures indicate faster recovery in the vitamin A group and negative in the placebo: fever: 0.03 (?0.10 to 0.17); oxygen requirement: ?0.08 (?0.31 to 0.16); raised respiratory rate: ?0.09 (?0.38 to 0.19); hospital stay: ?0.06 (?0.52 to 0.40). Mortality was below 2% in both groups, with a non-significantly higher risk in the intervention group (odds ratio 1.16, 95% CI: 0.61-2.21).

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More information

Published date: 2004
Keywords: acute lower respiratory tract infection, children, meta-analysis, randomized controlled trial, vitamin a

Identifiers

Local EPrints ID: 25282
URI: http://eprints.soton.ac.uk/id/eprint/25282
ISSN: 0803-5253
PURE UUID: 4c2917a7-4228-4dc1-b628-f49c75463d19

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Date deposited: 11 Apr 2006
Last modified: 15 Jul 2019 19:16

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Author: N. Brown
Author: C. Roberts

University divisions

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