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Incorporation of cis-9, trans-11 or trans-10, cis-12 conjugated linoleic acid into human erythrocytes in vivo

Incorporation of cis-9, trans-11 or trans-10, cis-12 conjugated linoleic acid into human erythrocytes in vivo
Incorporation of cis-9, trans-11 or trans-10, cis-12 conjugated linoleic acid into human erythrocytes in vivo
The purpose of this study was to determine the incorporation into erythrocytes of cis (c)-9,trans (t)-11 conjugated linoleic acid (CLA) and t10,c12 CLA consumed as supplements highly enriched in these isomers. Healthy men (31 ± 8 years) consumed 1, 2, and 4 capsules containing approximately 80 g/100 g of either c9,t11 CLA or t10,c12 CLA for sequential 8-week periods. Fatty acid concentrations in erythrocyte total lipids were determined at baseline and after consumption of the highest dose. The increase in c9,t11 CLA concentration (0.31 g/100 g) was significantly greater than that in t10,c12 CLA (0.19 g/100 g). This was associated with minor changes in concentrations of some fatty acids of chain length greater than 20 carbons. These data suggest selective assimilation of individual CLA isomers into erythrocyte lipids and partial substitution for specific saturated and polyunsaturated fatty acids.
conjugated linoleic acid, human, erythrocyte
0271-5317
13-19
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Derrick, Peter R.
a47d568b-f76e-4138-8f4d-b84de361627f
Russell, Jennifer J.
54a00b9a-1957-4583-ae3d-0ad1a8b4e016
Tricon, Sabine
4e65d971-4693-471f-bc7f-543c631b0363
Kew, Samantha
0388d70a-7691-4660-9896-95a45099a5db
Banerjee, Tapati
268e92f6-7802-44b4-a916-746c2433fa71
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Williams, Christine M.
4cf5b7be-8973-4ed3-9150-5caf74999670
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Derrick, Peter R.
a47d568b-f76e-4138-8f4d-b84de361627f
Russell, Jennifer J.
54a00b9a-1957-4583-ae3d-0ad1a8b4e016
Tricon, Sabine
4e65d971-4693-471f-bc7f-543c631b0363
Kew, Samantha
0388d70a-7691-4660-9896-95a45099a5db
Banerjee, Tapati
268e92f6-7802-44b4-a916-746c2433fa71
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Williams, Christine M.
4cf5b7be-8973-4ed3-9150-5caf74999670
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Burdge, Graham C., Derrick, Peter R., Russell, Jennifer J., Tricon, Sabine, Kew, Samantha, Banerjee, Tapati, Grimble, Robert F., Williams, Christine M., Yaqoob, Parveen and Calder, Philip C. (2005) Incorporation of cis-9, trans-11 or trans-10, cis-12 conjugated linoleic acid into human erythrocytes in vivo. Nutrition Research, 25 (1), 13-19. (doi:10.1016/j.nutres.2004.08.002).

Record type: Article

Abstract

The purpose of this study was to determine the incorporation into erythrocytes of cis (c)-9,trans (t)-11 conjugated linoleic acid (CLA) and t10,c12 CLA consumed as supplements highly enriched in these isomers. Healthy men (31 ± 8 years) consumed 1, 2, and 4 capsules containing approximately 80 g/100 g of either c9,t11 CLA or t10,c12 CLA for sequential 8-week periods. Fatty acid concentrations in erythrocyte total lipids were determined at baseline and after consumption of the highest dose. The increase in c9,t11 CLA concentration (0.31 g/100 g) was significantly greater than that in t10,c12 CLA (0.19 g/100 g). This was associated with minor changes in concentrations of some fatty acids of chain length greater than 20 carbons. These data suggest selective assimilation of individual CLA isomers into erythrocyte lipids and partial substitution for specific saturated and polyunsaturated fatty acids.

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More information

Published date: 2005
Additional Information: ISI:000227151200002
Keywords: conjugated linoleic acid, human, erythrocyte

Identifiers

Local EPrints ID: 25301
URI: http://eprints.soton.ac.uk/id/eprint/25301
ISSN: 0271-5317
PURE UUID: ec5412e1-c31e-4c92-aab1-784dd658278a
ORCID for Graham C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 26 Nov 2019 02:04

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Contributors

Author: Peter R. Derrick
Author: Jennifer J. Russell
Author: Sabine Tricon
Author: Samantha Kew
Author: Tapati Banerjee
Author: Robert F. Grimble
Author: Christine M. Williams
Author: Parveen Yaqoob

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