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Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids

Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids
Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids
The present study investigated whether consuming dairy products naturally enriched in cis-9, trans-11 (c9,t11) conjugated linoleic acid (CLA) by modification of cattle feed increases the concentration of this isomer in plasma and cellular lipids in healthy men. The study had a double-blind cross-over design. Subjects aged 34–60 years consumed dairy products available from food retailers for 1 week and then either control (0·17?g c9,t11 CLA/d; 0·31?g trans-vaccenic acid (tVA)/d) or CLA-enriched (1·43?g c9,t11 CLA/d; 4·71?g tVA/d) dairy products for 6 weeks. After 7 weeks washout, this was repeated with the alternate products. c9,t11 CLA concentration in plasma lipids was lower after consuming the control products, which may reflect the two-fold greater c9,t11 CLA content of the commercial products. Consuming the CLA-enriched dairy products increased the c9,t11 CLA concentration in plasma phosphatidylcholine (PC) (38?%; P=0·035), triacylglycerol (TAG) (22?%; P<0·0001) and cholesteryl esters (205?%; P<0·0001), and in peripheral blood mononuclear cells (PBMC) (238?%; P<0·0001), while tVA concentration was greater in plasma PC (65?%; P=0·035), TAG (98?%; P=0·001) and PBMC (84?%; P=0·004). Overall, the present study shows that consumption of naturally enriched dairy products in amounts similar to habitual intakes of these foods increased the c9,t11 CLA content of plasma and cellular lipids.
conjugated linoleic acid, blood lipids, human diet, dairy products
0007-1145
237-243
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Tricon, Sabine
4e65d971-4693-471f-bc7f-543c631b0363
Morgan, Rebecca
15e88c7f-36e5-4637-8812-e62a93c0076a
Kliem, Kirsty E.
f21260a3-6342-4c2c-8444-ae4e1522ab50
Childs, Caroline
ea17ccc1-2eac-4f67-96c7-a0c4d9dfd9c5
Jones, Emma
dd78e4a0-1029-4a53-a3a4-e622fb3d57c8
Russell, Jennifer J.
54a00b9a-1957-4583-ae3d-0ad1a8b4e016
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Williams, Christine M.
4cf5b7be-8973-4ed3-9150-5caf74999670
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Tricon, Sabine
4e65d971-4693-471f-bc7f-543c631b0363
Morgan, Rebecca
15e88c7f-36e5-4637-8812-e62a93c0076a
Kliem, Kirsty E.
f21260a3-6342-4c2c-8444-ae4e1522ab50
Childs, Caroline
ea17ccc1-2eac-4f67-96c7-a0c4d9dfd9c5
Jones, Emma
dd78e4a0-1029-4a53-a3a4-e622fb3d57c8
Russell, Jennifer J.
54a00b9a-1957-4583-ae3d-0ad1a8b4e016
Grimble, Robert F.
3100e4d2-8f29-4ca6-a95d-38a6a764865f
Williams, Christine M.
4cf5b7be-8973-4ed3-9150-5caf74999670
Yaqoob, Parveen
3a418e24-bbf0-4b31-9df8-ca8514885c82
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Burdge, Graham C., Tricon, Sabine, Morgan, Rebecca, Kliem, Kirsty E., Childs, Caroline, Jones, Emma, Russell, Jennifer J., Grimble, Robert F., Williams, Christine M., Yaqoob, Parveen and Calder, Philip C. (2005) Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids. British Journal of Nutrition, 94 (2), 237-243. (doi:10.1079/BJN20051506).

Record type: Article

Abstract

The present study investigated whether consuming dairy products naturally enriched in cis-9, trans-11 (c9,t11) conjugated linoleic acid (CLA) by modification of cattle feed increases the concentration of this isomer in plasma and cellular lipids in healthy men. The study had a double-blind cross-over design. Subjects aged 34–60 years consumed dairy products available from food retailers for 1 week and then either control (0·17?g c9,t11 CLA/d; 0·31?g trans-vaccenic acid (tVA)/d) or CLA-enriched (1·43?g c9,t11 CLA/d; 4·71?g tVA/d) dairy products for 6 weeks. After 7 weeks washout, this was repeated with the alternate products. c9,t11 CLA concentration in plasma lipids was lower after consuming the control products, which may reflect the two-fold greater c9,t11 CLA content of the commercial products. Consuming the CLA-enriched dairy products increased the c9,t11 CLA concentration in plasma phosphatidylcholine (PC) (38?%; P=0·035), triacylglycerol (TAG) (22?%; P<0·0001) and cholesteryl esters (205?%; P<0·0001), and in peripheral blood mononuclear cells (PBMC) (238?%; P<0·0001), while tVA concentration was greater in plasma PC (65?%; P=0·035), TAG (98?%; P=0·001) and PBMC (84?%; P=0·004). Overall, the present study shows that consumption of naturally enriched dairy products in amounts similar to habitual intakes of these foods increased the c9,t11 CLA content of plasma and cellular lipids.

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More information

Published date: 2005
Keywords: conjugated linoleic acid, blood lipids, human diet, dairy products
Organisations: Faculty of Medicine, Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 25302
URI: http://eprints.soton.ac.uk/id/eprint/25302
ISSN: 0007-1145
PURE UUID: c0ebf27f-20a0-44e3-907c-9a3551f224bb
ORCID for Graham C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967
ORCID for Caroline Childs: ORCID iD orcid.org/0000-0001-6832-224X

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 17 Dec 2019 02:01

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Contributors

Author: Sabine Tricon
Author: Rebecca Morgan
Author: Kirsty E. Kliem
Author: Caroline Childs ORCID iD
Author: Emma Jones
Author: Jennifer J. Russell
Author: Robert F. Grimble
Author: Christine M. Williams
Author: Parveen Yaqoob

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