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Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?

Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?
Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?
Chronic inflammation of the vascular endothelium produces endothelial dysfunction and ultimately atherogenesis. Postprandial hyperlipidaemia is an independent risk factor for cardiovascular disease. Recent studies show that the magnitude of postprandial lipaemia following a single fatty meal is negatively related to vascular function. This is associated with a transient increase in the concentrations of pro-inflammatory cytokines and soluble adhesion molecules and in pro-oxidant activity. One possible interpretation is that repeated exposure of the blood vessel wall to the activities of pro-inflammatory cytokines and pro-oxidants may damage the vascular endothelium and promote atherogenesis. Based on these results, we propose a model of a causal mechanism to explain how consumption of a fatty meal may impair vascular dysfunction.
vascular dysfunction, cytokines, postprandial, cardiovascular disease
0007-1145
3-9
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Burdge, Graham C.
09d60a07-8ca1-4351-9bf1-de6ffcfb2159
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Burdge, Graham C. and Calder, Philip C. (2005) Plasma cytokine response during the postprandial period: a potential causal process in vascular disease? British Journal of Nutrition, 93 (1), 3-9. (doi:10.1079/BJN20041282).

Record type: Article

Abstract

Chronic inflammation of the vascular endothelium produces endothelial dysfunction and ultimately atherogenesis. Postprandial hyperlipidaemia is an independent risk factor for cardiovascular disease. Recent studies show that the magnitude of postprandial lipaemia following a single fatty meal is negatively related to vascular function. This is associated with a transient increase in the concentrations of pro-inflammatory cytokines and soluble adhesion molecules and in pro-oxidant activity. One possible interpretation is that repeated exposure of the blood vessel wall to the activities of pro-inflammatory cytokines and pro-oxidants may damage the vascular endothelium and promote atherogenesis. Based on these results, we propose a model of a causal mechanism to explain how consumption of a fatty meal may impair vascular dysfunction.

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More information

Published date: 2005
Keywords: vascular dysfunction, cytokines, postprandial, cardiovascular disease

Identifiers

Local EPrints ID: 25303
URI: http://eprints.soton.ac.uk/id/eprint/25303
ISSN: 0007-1145
PURE UUID: 9e030c89-3c6f-440f-947c-8f46e0861df9
ORCID for Graham C. Burdge: ORCID iD orcid.org/0000-0002-7665-2967

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 10 Dec 2019 01:57

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