The University of Southampton
University of Southampton Institutional Repository

N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale?

N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale?
N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale?
Studies which have investigated the influence of increased consumption of n-3 polyunsaturated fatty acids (PUFA) upon indices of immune function in healthy humans are reviewed. Four studies have investigated the effects of ?-linolenic acid (ALNA; 2 to 18 g per day). Over 25 studies have investigated the effects of the long chain n-3 PUFA and these have used 0.55 to 14.4 g eicosapentaenoic acid (EPA) plus docosahexanoic acid (DHA) per day. Studies have been of 3 to 52 weeks duration. Most studies have examined the functions of immune cells ex vivo; there are a limited number of studies reporting in vivo measures of immune status/responses. High levels of either ALNA or EPA + DHA decrease chemotaxis of neutrophils and monocytes, production of reactive oxygen species by neutrophils and monocytes, production of pro-inflammatory cytokines by monocytes and T lymphocytes, and T lymphocyte proliferation. For most of these functions it is not possible to determine dose-response relationships because of experimental differences among studies. Thus, it is not clear what the level of n-3 PUFA required to exert the different effects is. The immunological effects of large amounts of n-3 PUFA suggest that they might be useful as therapies for diseases characterized by immune dysfunction. Evidence for beneficial effects of long chain n-3 PUFA in rheumatoid arthritis is strong and there is less strong evidence for benefit in Crohn’s disease, ulcerative colitis and psoriasis and among some adult asthmatics.
polyunsaturated fatty acid, fish oil, inflammation, immune function, eicosanoid, cytokine
0271-5317
309-341
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Calder, P.C. (2001) N-3 polyunsaturated fatty acids, inflammation and immunity: pouring oil on troubled waters or another fishy tale? Nutrition Research, 21 (1-2), 309-341. (doi:10.1016/S0271-5317(00)00287-6).

Record type: Article

Abstract

Studies which have investigated the influence of increased consumption of n-3 polyunsaturated fatty acids (PUFA) upon indices of immune function in healthy humans are reviewed. Four studies have investigated the effects of ?-linolenic acid (ALNA; 2 to 18 g per day). Over 25 studies have investigated the effects of the long chain n-3 PUFA and these have used 0.55 to 14.4 g eicosapentaenoic acid (EPA) plus docosahexanoic acid (DHA) per day. Studies have been of 3 to 52 weeks duration. Most studies have examined the functions of immune cells ex vivo; there are a limited number of studies reporting in vivo measures of immune status/responses. High levels of either ALNA or EPA + DHA decrease chemotaxis of neutrophils and monocytes, production of reactive oxygen species by neutrophils and monocytes, production of pro-inflammatory cytokines by monocytes and T lymphocytes, and T lymphocyte proliferation. For most of these functions it is not possible to determine dose-response relationships because of experimental differences among studies. Thus, it is not clear what the level of n-3 PUFA required to exert the different effects is. The immunological effects of large amounts of n-3 PUFA suggest that they might be useful as therapies for diseases characterized by immune dysfunction. Evidence for beneficial effects of long chain n-3 PUFA in rheumatoid arthritis is strong and there is less strong evidence for benefit in Crohn’s disease, ulcerative colitis and psoriasis and among some adult asthmatics.

Full text not available from this repository.

More information

Published date: 2001
Keywords: polyunsaturated fatty acid, fish oil, inflammation, immune function, eicosanoid, cytokine

Identifiers

Local EPrints ID: 25314
URI: https://eprints.soton.ac.uk/id/eprint/25314
ISSN: 0271-5317
PURE UUID: 57271a57-9ac6-41db-8e00-201b1a853c80

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 15 Jul 2019 19:16

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×