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Is there a case for n-3 fatty acid supplementation in cystic fibrosis?

Is there a case for n-3 fatty acid supplementation in cystic fibrosis?
Is there a case for n-3 fatty acid supplementation in cystic fibrosis?
Purpose of review: This review evaluates our current knowledge on the association of fatty acid abnormalities in cystic fibrosis with the disease process, and makes a case for a well-designed clinical trial to evaluate the clinical efficacy of long chain n-3 fatty acids.
Recent findings: It has long been known that cystic fibrosis patients exhibit fatty acid abnormalities, but these have not been well investigated in tissues affected by the disease. Recent studies have demonstrated that such tissues do indeed show abnormalities in the proportions of linoleic, arachidonic and docosahexaenoic acids, and have demonstrated alterations in fatty acid and phospholipid metabolism in cystic fibrosis. Work in other areas has identified novel anti-inflammatory actions of long chain n-3 fatty acids that might be relevant to cystic fibrosis. A recent systematic review of fish oil supplementation in cystic fibrosis did not allow firm conclusions to be drawn, but suggested that there may be some benefits.
Summary: The restoration of abnormal fatty acid profiles may be beneficial in cystic fibrosis, but this approach has not been evaluated in studies with a suitable design to permit firm conclusions to be drawn. There is a need for a long-term randomized controlled study to evaluate the therapeutic benefit of fish oil supplementation in cystic fibrosis.
153-159
Cawood, A. L.
4addc621-94ea-49b5-98c7-c15de5923315
Carroll, M. P.
79aa7536-798f-49cf-88a8-a0d66cb95bb4
Wootton, S. A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Calder, P. C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Cawood, A. L.
4addc621-94ea-49b5-98c7-c15de5923315
Carroll, M. P.
79aa7536-798f-49cf-88a8-a0d66cb95bb4
Wootton, S. A.
bf47ef35-0b33-4edb-a2b0-ceda5c475c0c
Calder, P. C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Cawood, A. L., Carroll, M. P., Wootton, S. A. and Calder, P. C. (2005) Is there a case for n-3 fatty acid supplementation in cystic fibrosis? Current Opinion in Clinical Nutrition and Metabolic Care, 8 (2), 153-159.

Record type: Article

Abstract

Purpose of review: This review evaluates our current knowledge on the association of fatty acid abnormalities in cystic fibrosis with the disease process, and makes a case for a well-designed clinical trial to evaluate the clinical efficacy of long chain n-3 fatty acids.
Recent findings: It has long been known that cystic fibrosis patients exhibit fatty acid abnormalities, but these have not been well investigated in tissues affected by the disease. Recent studies have demonstrated that such tissues do indeed show abnormalities in the proportions of linoleic, arachidonic and docosahexaenoic acids, and have demonstrated alterations in fatty acid and phospholipid metabolism in cystic fibrosis. Work in other areas has identified novel anti-inflammatory actions of long chain n-3 fatty acids that might be relevant to cystic fibrosis. A recent systematic review of fish oil supplementation in cystic fibrosis did not allow firm conclusions to be drawn, but suggested that there may be some benefits.
Summary: The restoration of abnormal fatty acid profiles may be beneficial in cystic fibrosis, but this approach has not been evaluated in studies with a suitable design to permit firm conclusions to be drawn. There is a need for a long-term randomized controlled study to evaluate the therapeutic benefit of fish oil supplementation in cystic fibrosis.

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Published date: 2005

Identifiers

Local EPrints ID: 25352
URI: http://eprints.soton.ac.uk/id/eprint/25352
PURE UUID: 58f6bad8-299c-4162-b55b-f4108e650b43

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Date deposited: 07 Apr 2006
Last modified: 06 Nov 2018 17:31

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