The University of Southampton
University of Southampton Institutional Repository

Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia

Record type: Article

Objective: An exaggerated inflammatory response has been implicated as the cause of endothelial cell dysfunction and the maternal syndrome of pre-eclampsia. Adhesion molecules play a central role in the adherence of leukocytes to endothelial cells and the subsequent migration of white blood cells into perivascular tissue. Cellular forms of adhesion molecules mediate specific steps of leukocyte-endothelial cell interaction, and have been implicated in the pathophysiology of pre-eclampsia. Soluble forms of these molecules can be detected in plasma, and their concentrations are thought to reflect the degree of activation of a particular cell type. Elevations in soluble P-selectin (sP-selectin) reflect platelet activation; changes in soluble L-selectin (sL-selectin) suggest leukocyte activation; and an increase in soluble forms of E-selectin (sE-selectin), vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1) and platelet endothelial cell adhesion molecule (sPECAM-1) indicate endothelial cell activation/dysfunction. The objective of this study was to determine whether normal pregnancy and pre-eclampsia were associated with changes in the concentrations of soluble selectins and members of the immunoglobulin superfamily of adhesion molecules.
Study design: A cross-sectional study was conducted to determine the plasma concentrations of sL-selectin, sE-selectin, sP-selectin, sVCAM-1, sICAM-1 and sPECAM-1 in peripheral blood obtained from non-pregnant women (n = 20), normal pregnant women (n = 100) and patients with pre-eclampsia (n = 55). Concentrations of soluble adhesion molecules were determined with enzyme-linked immunoassays. Parametric statistics were used for data analysis.
Results: Normal pregnancy was associated with a significant increase in the maternal plasma concentration of sP-selectin, a decrease in sL-selectin, and no change in sE-selectin, sVCAM-1, sICAM-1 and sPECAM-1. In contrast, pre-eclampsia was associated with a significant increase in sP-selectin, sE-selectin and sVCAM-1, a decrease in sL-selectin, but no change in sICAM-1 and sPECAM-1 concentrations.
Conclusions: The increased concentration of sP-selectin and decreased sL-selectin, as well as the lack of change in endothelial cell-associated soluble adhesion molecules suggest that pregnancy is associated with platelet and leukocyte activation, but not endothelial cell activation. In contrast, pre-eclampsia appears to be characterized by activation of platelets, leukocytes and endothelial cells.

Full text not available from this repository.

Citation

Chaiworapongsa, T., Romero, R., Yoshimatsu, J., Espinoza, J., Kim, Y.M., Park, K., Kalache, K.D., Edwin, S., Bujold, E. and Gomez, R. (2002) Soluble adhesion molecule profile in normal pregnancy and pre-eclampsia Journal of Maternal-Fetal & Neonatal Medicine, 12, (1), pp. 19-27.

More information

Published date: 2002
Keywords: adhesion molecules, normal pregnancy, pre-eclampsia, selectins, endothelium, leukocytes, platelets

Identifiers

Local EPrints ID: 25354
URI: http://eprints.soton.ac.uk/id/eprint/25354
ISSN: 1476-7058
PURE UUID: f15c4013-6f59-43f7-ad2b-a8e9c5270e05

Catalogue record

Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:11

Export record

Contributors

Author: T. Chaiworapongsa
Author: R. Romero
Author: J. Yoshimatsu
Author: J. Espinoza
Author: Y.M. Kim
Author: K. Park
Author: K.D. Kalache
Author: S. Edwin
Author: E. Bujold
Author: R. Gomez

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×