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Subclinical myocardial injury in small-for-gestational-age neonates

Record type: Article

Objective: Small-for-gestational-age (SGA) infants are at risk for premature death from cardiovascular disease (myocardial infarction and stroke), hypertension, and diabetes in adult life. Severe intrauterine growth restriction is often associated with subclinical cardiovascular abnormalities detectable during fetal echocardiography. The objective of this study was to determine whether SGA newborns have evidence of myocardial injury at birth.
Study design: Cardiac troponin I, a specific marker of myocardial injury widely used for the diagnosis of myocardial infarction in adults, was determined in umbilical cord blood. Umbilical cord venous blood was obtained at the time of birth from 72 SGA newborns (birth weight below the 10th centile for gestational age) and 309 newborns whose birth weights were appropriate for gestational age (AGA). Cardiac troponin I was determined with a commercially available immunoassay (sensitivity 0.2 ng/ml) employed in clinical laboratories (Immulite 2000, Diagnostic Products Corp., Los Angeles, CA).
Results: Cardiac troponin I was not detectable in any of the blood samples from AGA infants. In contrast, 4.2% (3/72) of SGA infants had detectable cardiac troponin I in umbilical cord blood (Fisher's exact test, p = 0.007).
Conclusion: A subgroup of SGA newborns undergoes myocardial injury before birth. This insult may predispose to the development of adult premature cardiovascular disease and death.

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Citation

Chaiworapongsa, T., Espinoza, J., Yoshimatsu, J., Kalache, K.D., Edwin, S., Blackwell, S., Yoon, B.H., Tolosa, J.E., Silva, M., Behnke, E., Gomez, R. and Romero, R. (2002) Subclinical myocardial injury in small-for-gestational-age neonates Journal of Maternal-Fetal & Neonatal Medicine, 11, (6), pp. 385-390.

More information

Published date: 2002
Keywords: small for gestational age, troponin i, myocardial injury

Identifiers

Local EPrints ID: 25355
URI: http://eprints.soton.ac.uk/id/eprint/25355
ISSN: 1476-7058
PURE UUID: 0a1efd85-26b4-4f60-867c-bf314839f38c

Catalogue record

Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:11

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Contributors

Author: T. Chaiworapongsa
Author: J. Espinoza
Author: J. Yoshimatsu
Author: K.D. Kalache
Author: S. Edwin
Author: S. Blackwell
Author: B.H. Yoon
Author: J.E. Tolosa
Author: M. Silva
Author: E. Behnke
Author: R. Gomez
Author: R. Romero

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