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Growth hormone predicts bone density in elderly women

Growth hormone predicts bone density in elderly women
Growth hormone predicts bone density in elderly women
Evidence is accumulating that the risk of osteoporosis may be influenced by environmental factors during intrauterine and early postnatal life; such programming might be mediated through modification of the GH/IGF-1 axis during critical periods in its development. To address this issue, we explored the relationships among birth weight, circulating GH profile, bone density, and bone loss rate in a group of British women. The study population consisted of 38 women 60–75 years old resident in Hertfordshire for whom detailed birth records were available. Twenty-four-hour circulating GH profiles were obtained during an inpatient stay on a metabolic ward, after an overnight rest. The circulating profile of GH was characterised by estimating the peak, median, trough, and total concentrations from 72 samples measured sequentially over 24 h in each subject. Bone mineral density was assessed at the lumbar spine and femoral neck at baseline and at follow-up 4 years later. Lumbar spine bone mineral content (BMC) and density (BMD) were positively associated with all measures of GH concentration, although relationships were strongest for BMC with trough GH (r = 0.47, P < 0.01). Associations persisted after adjustment for age, body mass index, smoking, alcohol consumption, physical activity, and osteoarthritis score in multiple regression models. However, associations of GH concentration with femoral neck BMC were weak, and there was no association between any measure of GH concentration and bone loss at either site. Total (integrated) daily GH concentration tended to increase (P = 0.08) with rising birth weight, while IGF-1 concentration fell (P = 0.05) with rising birth weight, suggesting a role for the GH/IGF-1 axis in the programming of adult bone mass among women.
osteoporosis, epidemiology, growth hormone, programming, birth weight
8756-3282
434-440
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Hindmarsh, P.C.
904f77fe-a440-40a1-8729-3a4e8e7ed5d5
Kellingray, S.
418e1aef-0230-450a-a9b7-ba8cf0e7fba9
Fall, C.H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Hindmarsh, P.C.
904f77fe-a440-40a1-8729-3a4e8e7ed5d5
Kellingray, S.
418e1aef-0230-450a-a9b7-ba8cf0e7fba9
Fall, C.H.D.
7171a105-34f5-4131-89d7-1aa639893b18
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Dennison, E.M., Hindmarsh, P.C., Kellingray, S., Fall, C.H.D. and Cooper, C. (2003) Growth hormone predicts bone density in elderly women. Bone, 32 (4), 434-440. (doi:10.1016/S8756-3282(03)00035-8).

Record type: Article

Abstract

Evidence is accumulating that the risk of osteoporosis may be influenced by environmental factors during intrauterine and early postnatal life; such programming might be mediated through modification of the GH/IGF-1 axis during critical periods in its development. To address this issue, we explored the relationships among birth weight, circulating GH profile, bone density, and bone loss rate in a group of British women. The study population consisted of 38 women 60–75 years old resident in Hertfordshire for whom detailed birth records were available. Twenty-four-hour circulating GH profiles were obtained during an inpatient stay on a metabolic ward, after an overnight rest. The circulating profile of GH was characterised by estimating the peak, median, trough, and total concentrations from 72 samples measured sequentially over 24 h in each subject. Bone mineral density was assessed at the lumbar spine and femoral neck at baseline and at follow-up 4 years later. Lumbar spine bone mineral content (BMC) and density (BMD) were positively associated with all measures of GH concentration, although relationships were strongest for BMC with trough GH (r = 0.47, P < 0.01). Associations persisted after adjustment for age, body mass index, smoking, alcohol consumption, physical activity, and osteoarthritis score in multiple regression models. However, associations of GH concentration with femoral neck BMC were weak, and there was no association between any measure of GH concentration and bone loss at either site. Total (integrated) daily GH concentration tended to increase (P = 0.08) with rising birth weight, while IGF-1 concentration fell (P = 0.05) with rising birth weight, suggesting a role for the GH/IGF-1 axis in the programming of adult bone mass among women.

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More information

Published date: 2003
Keywords: osteoporosis, epidemiology, growth hormone, programming, birth weight

Identifiers

Local EPrints ID: 25407
URI: https://eprints.soton.ac.uk/id/eprint/25407
ISSN: 8756-3282
PURE UUID: 8ccc4620-a889-40da-bd03-93b4ca9e547a
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 20 Jul 2019 01:17

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