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Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire Cohort Study

Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire Cohort Study
Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire Cohort Study
Several studies have shown an association between circulating leptin concentration and bone mineral density, but most studies are cross-sectional in design and report findings in women only. We performed a population-based longitudinal study relating baseline plasma leptin concentration to bone mass at the lumbar spine and femoral neck and to change in bone density at these sites over four years in a cohort of 302 men and women aged 60–75 years born and still resident in Hertfordshire, UK. Baseline plasma leptin concentration was strongly positively correlated with body mass index (men: r = 0.71, P < 0.000l; women: r = 0.79, P < 0.0001) and with bone mineral content, bone mineral density, and volumetric bone mineral density at all sites (r = 0.24–0.36, P < 0.001) in both sexes; associations with change in bone density were markedly weaker and inconsistent. Adjustment for adult lifestyle determinants of osteoporosis made little difference to our results, but the associations of leptin with bone mass were no longer significant after adjustment for body mass index. These results suggest that the relationship between plasma leptin and bone mass is similar in men and women and that it is mediated through the strong association of both variables with adiposity, rather than through a direct association of leptin on bone cell function.
epidemiology, osteoporosis, leptin, obesity, bone density
0171-967X
401-406
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Fall, C.H.
7171a105-34f5-4131-89d7-1aa639893b18
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Phillips, D.I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Fall, C.H.
7171a105-34f5-4131-89d7-1aa639893b18
Javaid, M.K.
51d3310b-032e-4c15-83ac-b878bce090f3
Arden, N.K.
23af958d-835c-4d79-be54-4bbe4c68077f
Phillips, D.I.W.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Dennison, E.M., Syddall, H.E., Fall, C.H., Javaid, M.K., Arden, N.K., Phillips, D.I.W. and Cooper, C. (2004) Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire Cohort Study. Calcified Tissue International, 74 (5), 401-406. (doi:10.1007/s00223-002-0017-x).

Record type: Article

Abstract

Several studies have shown an association between circulating leptin concentration and bone mineral density, but most studies are cross-sectional in design and report findings in women only. We performed a population-based longitudinal study relating baseline plasma leptin concentration to bone mass at the lumbar spine and femoral neck and to change in bone density at these sites over four years in a cohort of 302 men and women aged 60–75 years born and still resident in Hertfordshire, UK. Baseline plasma leptin concentration was strongly positively correlated with body mass index (men: r = 0.71, P < 0.000l; women: r = 0.79, P < 0.0001) and with bone mineral content, bone mineral density, and volumetric bone mineral density at all sites (r = 0.24–0.36, P < 0.001) in both sexes; associations with change in bone density were markedly weaker and inconsistent. Adjustment for adult lifestyle determinants of osteoporosis made little difference to our results, but the associations of leptin with bone mass were no longer significant after adjustment for body mass index. These results suggest that the relationship between plasma leptin and bone mass is similar in men and women and that it is mediated through the strong association of both variables with adiposity, rather than through a direct association of leptin on bone cell function.

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More information

Published date: 2004
Keywords: epidemiology, osteoporosis, leptin, obesity, bone density

Identifiers

Local EPrints ID: 25408
URI: https://eprints.soton.ac.uk/id/eprint/25408
ISSN: 0171-967X
PURE UUID: d827791b-189e-4092-b641-ea0792db54ab
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for H.E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 07 Apr 2006
Last modified: 20 Jul 2019 01:17

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