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Evidence of sexual dimorphism in relationships between estrogen receptor polymorphisms and bone mass: the Hertfordshire study

Evidence of sexual dimorphism in relationships between estrogen receptor polymorphisms and bone mass: the Hertfordshire study
Evidence of sexual dimorphism in relationships between estrogen receptor polymorphisms and bone mass: the Hertfordshire study
Objective: to examine the relationship between estrogen receptor (ER) a and ß gene polymorphisms and bone mass.
Methods: bone mineral density (BMD) was measured at the lumbar spine and proximal femur twice, 4 years apart, in a cohort of 147 men and 125 women aged 61-73 years. Genomic DNA was extracted from whole blood samples, and genotyping for the ER (PvuII, XbaI, and AluI) was undertaken.
Results: there were no significant associations between either the XbaI or PvuII polymorphisms and bone mass, or bone loss in the cohort as a whole. However, men homozygous for the aa ß receptor polymorphism had higher BMD at the lumbar spine (p = 0.05), femoral neck (p = 0.01), and total femur (p = 0.01). Women homozygous for aa had lower femoral neck and total femoral BMD than women of the AA or Aa genotypes (p = 0.01 and p = 0.02). Gender*ERß interaction terms were statistically significant (p = 0.02 for lumbar spine BMD, p = 0.0004 for femoral neck BMD, and p = 0.0003 for total femoral BMD, each test with 2 degrees of freedom unadjusted). Adjustment for sex hormone concentration and lifestyle factors made little difference to our results.
Conclusion: we found relationships between the ERß gene and the determination of bone mass among men and women in their seventh decade.
estrogen receptor, interaction, bone
0315-162X
2400-2404
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Syddall, Holly
a0181a93-8fc3-4998-a996-7963f0128328
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Cooper, Cyrus
dcc9d567-2d74-410d-84eb-3487f1697f44
Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Syddall, Holly
a0181a93-8fc3-4998-a996-7963f0128328
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Cooper, Cyrus
dcc9d567-2d74-410d-84eb-3487f1697f44

Dennison, Elaine, Syddall, Holly, Fall, Caroline and Cooper, Cyrus (2005) Evidence of sexual dimorphism in relationships between estrogen receptor polymorphisms and bone mass: the Hertfordshire study. The Journal of Rheumatology, 32 (12), 2400-2404.

Record type: Article

Abstract

Objective: to examine the relationship between estrogen receptor (ER) a and ß gene polymorphisms and bone mass.
Methods: bone mineral density (BMD) was measured at the lumbar spine and proximal femur twice, 4 years apart, in a cohort of 147 men and 125 women aged 61-73 years. Genomic DNA was extracted from whole blood samples, and genotyping for the ER (PvuII, XbaI, and AluI) was undertaken.
Results: there were no significant associations between either the XbaI or PvuII polymorphisms and bone mass, or bone loss in the cohort as a whole. However, men homozygous for the aa ß receptor polymorphism had higher BMD at the lumbar spine (p = 0.05), femoral neck (p = 0.01), and total femur (p = 0.01). Women homozygous for aa had lower femoral neck and total femoral BMD than women of the AA or Aa genotypes (p = 0.01 and p = 0.02). Gender*ERß interaction terms were statistically significant (p = 0.02 for lumbar spine BMD, p = 0.0004 for femoral neck BMD, and p = 0.0003 for total femoral BMD, each test with 2 degrees of freedom unadjusted). Adjustment for sex hormone concentration and lifestyle factors made little difference to our results.
Conclusion: we found relationships between the ERß gene and the determination of bone mass among men and women in their seventh decade.

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More information

Published date: 2005
Keywords: estrogen receptor, interaction, bone
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 25413
URI: https://eprints.soton.ac.uk/id/eprint/25413
ISSN: 0315-162X
PURE UUID: 2acbbfae-95c7-4ea0-8422-74e7439a115b
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Holly Syddall: ORCID iD orcid.org/0000-0003-0171-0306

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 10 Jan 2019 01:37

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Contributors

Author: Elaine Dennison ORCID iD
Author: Holly Syddall ORCID iD
Author: Caroline Fall
Author: Cyrus Cooper

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