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Relationship of maternal protein turnover and lean body mass during pregnancy and birth length

Relationship of maternal protein turnover and lean body mass during pregnancy and birth length
Relationship of maternal protein turnover and lean body mass during pregnancy and birth length
Epidemiological evidence shows that small size at birth is associated with an increased risk of developing cardiovascular and metabolic disease in adult life. We have examined the relationships between size at birth and maternal body composition and protein turnover in normal pregnant women. A group of 27 multiparous Caucasian women with singleton pregnancies were studied at around 18 and 28 weeks' gestation. Body composition was determined by anthropometry, and whole-body protein turnover was estimated by using a single oral dose of [15N]glycine and the end-product method. The baby's weight and length were measured within 48 h of birth. Mothers with a greater lean body mass had higher rates of protein turnover at 18 weeks' gestation. This association was largely accounted for by differences in the mother's visceral, rather than muscle, mass. Mothers who had higher protein turnover at 18 weeks' gestation had babies that were longer at birth. After adjustment for the duration of gestation and the baby's sex, 26% of the variation in length at birth was accounted for by maternal protein synthesis at 18 weeks' gestation. Maternal protein intake was not associated with the baby's birth length. Thus the mother's ability to nourish her fetus is influenced by her body composition and her rate of protein turnover. Dietary intake does not adequately characterize this ability.
birth length, birth weight, glycine, 15N, pregnancy, protein synthesis, protein turnover
0143-5221
65-72
Duggleby, Sarah L.
2077aa39-da37-4932-98cb-e15a454ad6b3
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef
Duggleby, Sarah L.
2077aa39-da37-4932-98cb-e15a454ad6b3
Jackson, Alan A.
c9a12d7c-b4d6-4c92-820e-890a688379ef

Duggleby, Sarah L. and Jackson, Alan A. (2001) Relationship of maternal protein turnover and lean body mass during pregnancy and birth length. Clinical Science, 101 (1), 65-72.

Record type: Article

Abstract

Epidemiological evidence shows that small size at birth is associated with an increased risk of developing cardiovascular and metabolic disease in adult life. We have examined the relationships between size at birth and maternal body composition and protein turnover in normal pregnant women. A group of 27 multiparous Caucasian women with singleton pregnancies were studied at around 18 and 28 weeks' gestation. Body composition was determined by anthropometry, and whole-body protein turnover was estimated by using a single oral dose of [15N]glycine and the end-product method. The baby's weight and length were measured within 48 h of birth. Mothers with a greater lean body mass had higher rates of protein turnover at 18 weeks' gestation. This association was largely accounted for by differences in the mother's visceral, rather than muscle, mass. Mothers who had higher protein turnover at 18 weeks' gestation had babies that were longer at birth. After adjustment for the duration of gestation and the baby's sex, 26% of the variation in length at birth was accounted for by maternal protein synthesis at 18 weeks' gestation. Maternal protein intake was not associated with the baby's birth length. Thus the mother's ability to nourish her fetus is influenced by her body composition and her rate of protein turnover. Dietary intake does not adequately characterize this ability.

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More information

Published date: July 2001
Keywords: birth length, birth weight, glycine, 15N, pregnancy, protein synthesis, protein turnover

Identifiers

Local EPrints ID: 25418
URI: https://eprints.soton.ac.uk/id/eprint/25418
ISSN: 0143-5221
PURE UUID: 6a0e5e8d-c5ed-4885-9c44-e66e2e478dc8

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Date deposited: 07 Apr 2006
Last modified: 17 Jul 2017 16:11

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Contributors

Author: Sarah L. Duggleby
Author: Alan A. Jackson

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