Statins and bone: myth or reality?
Statins and bone: myth or reality?
In the space of a few weeks, four articles appeared in The Lancet and JAMA suggesting that using 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) is associated with increased bone mineral density (BMD) [1] and a reduced fracture risk [2, 3, 4][2-4]. The stimulus for these case-control studies came from reports that the statins have unexpected effects on bone, increasing bone formation in rodents [5]. These observations offered a new insight into the potential importance of the cholesterol synthesis pathway in bone turnover and future therapeutic opportunities.
63-66
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106
Russell, R.G.G.
a0756c8a-20ea-4d47-b207-61c1ec37a529
Spector, T.D.
87d1f285-3f22-4c9a-b006-d65cfda6d3e0
2001
Edwards, C.J.
dcb27fec-75ea-4575-a844-3588bcf14106
Russell, R.G.G.
a0756c8a-20ea-4d47-b207-61c1ec37a529
Spector, T.D.
87d1f285-3f22-4c9a-b006-d65cfda6d3e0
Edwards, C.J., Russell, R.G.G. and Spector, T.D.
(2001)
Statins and bone: myth or reality?
Calcified Tissue International, 69 (2), .
(doi:10.1007/s00223-001-2017-7).
Abstract
In the space of a few weeks, four articles appeared in The Lancet and JAMA suggesting that using 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) is associated with increased bone mineral density (BMD) [1] and a reduced fracture risk [2, 3, 4][2-4]. The stimulus for these case-control studies came from reports that the statins have unexpected effects on bone, increasing bone formation in rodents [5]. These observations offered a new insight into the potential importance of the cholesterol synthesis pathway in bone turnover and future therapeutic opportunities.
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Published date: 2001
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Local EPrints ID: 25430
URI: http://eprints.soton.ac.uk/id/eprint/25430
ISSN: 0171-967X
PURE UUID: 767ceb33-12ff-4822-8721-524975934b68
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Date deposited: 06 Apr 2006
Last modified: 15 Mar 2024 07:02
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Author:
R.G.G. Russell
Author:
T.D. Spector
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