Statins as modulators of bone formation
Statins as modulators of bone formation
The use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) to reduce serum cholesterol is well described. However, the recent finding that statins have direct effects on bone was unexpected. A number of epidemiological studies have recently been published that explore the effects of statins on bone mineral density and risk of fracture in humans. Statins may act by directly stimulating the expression of bone morphogenetic protein-2 and increasing osteoblast differentiation or, like nitrogen-containing bisphosphonates, may have effects on the mevalonate pathway that leads to inhibition of osteoclast activity and osteoblast apoptosis. In addition, the demonstration that statins can inhibit inflammation and encourage angiogenesis offers other possibilities for action.
angiogenesis, bone morphogenetic proteins, fracture, inflammation, statins
151-153
Edwards, Christopher J.
dcb27fec-75ea-4575-a844-3588bcf14106
Spector, Tim D.
1e47066c-6620-4f86-af6f-89d9e130ffc2
2002
Edwards, Christopher J.
dcb27fec-75ea-4575-a844-3588bcf14106
Spector, Tim D.
1e47066c-6620-4f86-af6f-89d9e130ffc2
Edwards, Christopher J. and Spector, Tim D.
(2002)
Statins as modulators of bone formation.
Arthritis Research, 4 (3), .
(doi:10.1186/ar399).
Abstract
The use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) to reduce serum cholesterol is well described. However, the recent finding that statins have direct effects on bone was unexpected. A number of epidemiological studies have recently been published that explore the effects of statins on bone mineral density and risk of fracture in humans. Statins may act by directly stimulating the expression of bone morphogenetic protein-2 and increasing osteoblast differentiation or, like nitrogen-containing bisphosphonates, may have effects on the mevalonate pathway that leads to inhibition of osteoclast activity and osteoblast apoptosis. In addition, the demonstration that statins can inhibit inflammation and encourage angiogenesis offers other possibilities for action.
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Published date: 2002
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Keywords:
angiogenesis, bone morphogenetic proteins, fracture, inflammation, statins
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Local EPrints ID: 25434
URI: http://eprints.soton.ac.uk/id/eprint/25434
ISSN: 1465-9905
PURE UUID: 994f0676-852c-457e-a338-cf5644f0edd1
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Date deposited: 06 Apr 2006
Last modified: 15 Mar 2024 07:02
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Author:
Tim D. Spector
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