The effects of the Pro12Ala polymorphism of the PPAR?-2 gene on lipid metabolism interact with body size at birth
The effects of the Pro12Ala polymorphism of the PPAR?-2 gene on lipid metabolism interact with body size at birth
Body size at birth is an indicator of the intrauterine environment. The effects of the Pro12Pro genotype and the 12Ala allele of the PPAR?-2 gene on glucose and insulin metabolism in adult life depend on body size at birth. A low birth weight is associated with insulin resistance and type 2 diabetes. The peroxisome proliferator-activated receptor-? (PPAR?s) are also regulators of adipocyte differentiation, and the PPAR?-2 gene could also contribute to the development of dyslipidemia. Therefore, the effects of the Pro12Ala polymorphisms of the PPAR?-2 gene on lipid metabolism were measured in 476 elderly persons whose birth weight was known. The Ala12 allele was associated with increased serum total, low-density lipoprotein (LDL), and non-high-density lipoprotein (non-HDL) cholesterol concentrations but only among those who had birth weights below 3000 g. These interactions between the effects of the PPAR?-2 gene on adult traits and the effects of birth weight may be interpreted as examples of gene–environmental interactions, which underlie plasticity during development.
birth weight, developmental plasticity, dyslipidemia, gene-enviroment interaction, ppar?-2gene
366-370
Eriksson, J.
e82bcabe-c143-4fc5-9755-a03639b52b2c
Lindi, V.
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Uusitupa, M.
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Forsen, T.
009ce53c-8bbf-4c5c-a21f-0bbdd1f999c4
Laakso, M.
ec6734f9-b924-430e-89a0-47fa5c66110d
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.
4da1905f-11d2-4673-b261-1895f6455e2b
2003
Eriksson, J.
e82bcabe-c143-4fc5-9755-a03639b52b2c
Lindi, V.
786eadf8-d0f4-4e80-b147-7054a98744eb
Uusitupa, M.
0b80be97-ba89-475e-aa3b-b440470357d6
Forsen, T.
009ce53c-8bbf-4c5c-a21f-0bbdd1f999c4
Laakso, M.
ec6734f9-b924-430e-89a0-47fa5c66110d
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.
4da1905f-11d2-4673-b261-1895f6455e2b
Eriksson, J., Lindi, V., Uusitupa, M., Forsen, T., Laakso, M., Osmond, C. and Barker, D.
(2003)
The effects of the Pro12Ala polymorphism of the PPAR?-2 gene on lipid metabolism interact with body size at birth.
Clinical Genetics, 64 (4), .
(doi:10.1034/j.1399-0004.2003.00150.x).
Abstract
Body size at birth is an indicator of the intrauterine environment. The effects of the Pro12Pro genotype and the 12Ala allele of the PPAR?-2 gene on glucose and insulin metabolism in adult life depend on body size at birth. A low birth weight is associated with insulin resistance and type 2 diabetes. The peroxisome proliferator-activated receptor-? (PPAR?s) are also regulators of adipocyte differentiation, and the PPAR?-2 gene could also contribute to the development of dyslipidemia. Therefore, the effects of the Pro12Ala polymorphisms of the PPAR?-2 gene on lipid metabolism were measured in 476 elderly persons whose birth weight was known. The Ala12 allele was associated with increased serum total, low-density lipoprotein (LDL), and non-high-density lipoprotein (non-HDL) cholesterol concentrations but only among those who had birth weights below 3000 g. These interactions between the effects of the PPAR?-2 gene on adult traits and the effects of birth weight may be interpreted as examples of gene–environmental interactions, which underlie plasticity during development.
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Published date: 2003
Keywords:
birth weight, developmental plasticity, dyslipidemia, gene-enviroment interaction, ppar?-2gene
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Local EPrints ID: 25466
URI: http://eprints.soton.ac.uk/id/eprint/25466
ISSN: 0009-9163
PURE UUID: d05e0d00-22cc-429b-8c2c-10f675d191ec
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Date deposited: 19 Apr 2006
Last modified: 16 Mar 2024 02:50
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Author:
J. Eriksson
Author:
V. Lindi
Author:
M. Uusitupa
Author:
T. Forsen
Author:
M. Laakso
Author:
D. Barker
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