The University of Southampton
University of Southampton Institutional Repository

Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals

Eriksson, J.G., Forsen, T., Tuomilehto, J., Jaddoe, V.W., Osmond, C. and Barker, D.J.P. (2002) Effects of size at birth and childhood growth on the insulin resistance syndrome in elderly individuals Diabetologia, 45, (3), pp. 342-348. (doi:10.1007/s00125-001-0757-6).

Record type: Article

Abstract

Aims/hypothesis: A study of 7086 men and women born in Helsinki, Finland, has shown that the development of Type II (non-insulin-dependent) diabetes mellitus is associated with low birth weight followed by accelerated gain in height and weight during childhood and with high maternal BMI but the processes which underlie these associations are largely not known.
Methods: We carried out standard oral glucose tolerance tests, and measured plasma insulin and proinsulin, serum lipid concentrations and blood pressure in 474 patients from the Helsinki cohort.
Results: We used four indices of insulin resistance: fasting and 2-h plasma insulin, and fasting proinsulin and 32-33 split proinsulin concentrations. These were associated with small body size at birth and during childhood, rapid growth in height and low maternal BMI.
Conclusion/interpretation: Insulin resistance and Type II diabetes share common associations with retarded fetal growth and accelerated growth during childhood. They are dissimilar, however, in that insulin resistance is associated with thinness in childhood and low maternal BMI, while Type II diabetes is associated with high BMI in childhood and high maternal BMI.

Full text not available from this repository.

More information

Published date: 2002
Keywords: fetal growth, childhood growth, maternal weight, insulin resistance, type ii diabetes

Identifiers

Local EPrints ID: 25468
URI: http://eprints.soton.ac.uk/id/eprint/25468
ISSN: 0012-186X
PURE UUID: 4aa788e9-8fa8-40b6-9a52-dfb46347a333
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:10

Export record

Altmetrics

Contributors

Author: J.G. Eriksson
Author: T. Forsen
Author: J. Tuomilehto
Author: V.W. Jaddoe
Author: C. Osmond ORCID iD
Author: D.J.P. Barker

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×