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The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-?2 gene on insulin sensitivity and insulin metabolism interact with size at birth

Eriksson, Johan G., Lindi, Virpi, Uusitupa, Matti, Forsen, Tom J., Laakso, Markku, Osmond, Clive and Barker, David J. P. (2002) The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-?2 gene on insulin sensitivity and insulin metabolism interact with size at birth Diabetes, 51, (7), pp. 2321-2324.

Record type: Article

Abstract

Type 2 diabetes is known to be associated with a small body size at birth. Body size at birth is an indicator of the intrauterine environment. There is also a well-established association between the peroxisome proliferator-activated receptor (PPAR)-?2 gene and type 2 diabetes. We therefore assessed whether the effects of the Pro12Ala polymorphism of the PPAR-?2 gene on insulin sensitivity and insulin concentrations in adult life are modified by size at birth. We found that the effects of the Pro12Pro and Pro12Ala polymorphisms of the PPAR-?2 gene in elderly people depended on their body size at birth. The well-known association between small body size at birth and insulin resistance was seen only in individuals with the high-risk Pro12Pro allele. In those who had low birth weight, the Pro12Pro polymorphism of the PPAR-?2 gene was associated with increased insulin resistance (P < 0.002) and elevated insulin concentrations (P < 0.003). These interactions between the effects of the Pro12Ala polymorphisms of the PPAR-?2 gene on adult traits and the effects of birth weight link two previously unknown associations together within the context of type 2 diabetes. We suggest that these findings reflect gene-environment interaction.

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More information

Published date: 2002
Additional Information: Brief Genetics Report

Identifiers

Local EPrints ID: 25469
URI: http://eprints.soton.ac.uk/id/eprint/25469
ISSN: 0012-1797
PURE UUID: 659abb2e-0556-442e-84fb-2d3ee66f1960
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655

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Date deposited: 12 Apr 2006
Last modified: 17 Jul 2017 16:10

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Contributors

Author: Johan G. Eriksson
Author: Virpi Lindi
Author: Matti Uusitupa
Author: Tom J. Forsen
Author: Markku Laakso
Author: Clive Osmond ORCID iD
Author: David J. P. Barker

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