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Ontogeny of pulmonary and renal angiotensin-converting enzyme in pigs

Forhead, Alison J., Gulati, Vivek, Poore, Kirsten R. and Fowden, Abigail L. (2001) Ontogeny of pulmonary and renal angiotensin-converting enzyme in pigs Molecular and Cellular Endocrinology, 185, (1-2), pp. 127-133. (doi:10.1016/S0303-7207(01)00623-2).

Record type: Article


The present study investigated the ontogeny of pulmonary and renal angiotensin-converting enzyme (ACE) in foetal and postnatal pigs, and examined the effect of cortisol on tissue ACE in utero. Data were compared with those in sheep at similar ages. Under anaesthesia, tissues and umbilical blood were collected from pig foetuses between 81–115 days of gestation (term, 115±2 days). Twelve foetuses delivered at 97±2 days were infused with saline or cortisol (3–6 mg kg?1 day?1) using osmotic mini-pumps implanted 6 days previously. Tissues were collected from newborn piglets, and from pigs at 2–4 weeks, 10–12 weeks and 10–12 months of age. Unlike in sheep, gestational age and exogenous cortisol had no effect on pulmonary or renal ACE in pigs. After birth, pulmonary ACE decreased to a nadir at 2–4 weeks and remained low thereafter. Renal ACE increased between 10–12 weeks and 10–12 months. Postnatal changes in tissue ACE may have consequences for cardiovascular, pulmonary and renal function in pigs.

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Published date: 2001
Keywords: angiotensin, foetus, cortisol, pig lung, pig kidney


Local EPrints ID: 25502
PURE UUID: dde908db-9d1e-4f6c-a64b-990d9ac1fe02
ORCID for Kirsten R. Poore: ORCID iD

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Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:10

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Author: Alison J. Forhead
Author: Vivek Gulati
Author: Abigail L. Fowden

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