The developmental origins of the metabolic syndrome


Gluckman, Peter D. and Hanson, Mark A. (2004) The developmental origins of the metabolic syndrome Trends in Endocrinology and Metabolism, 15, (4), pp. 183-187. (doi:10.1016/j.tem.2004.03.002).

Download

Full text not available from this repository.

Description/Abstract

Both epidemiological and clinical evidence suggest relationships between the antenatal environment and the risk of developing insulin resistance and associated cardiovascular disease (part of the metabolic syndrome) in middle age. However, interpretation of these findings has been controversial. Recent experimental observations provide considerable evidence for a causal model linking adaptive responses to early environmental cues and the later risk of disease. Evolutionary and life history theory provide possible explanations of why these phenomena have persisted and how they might cause disease. In this article, we review the clinical and experimental perspectives on the ‘developmental origins of disease’ model in the context of these new concepts.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.tem.2004.03.002
ISSNs: 1043-2760 (print)
Related URLs:
Subjects:
ePrint ID: 25542
Date :
Date Event
2004Published
Date Deposited: 07 Apr 2006
Last Modified: 16 Apr 2017 22:36
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/25542

Actions (login required)

View Item View Item