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The developmental origins of the metabolic syndrome

The developmental origins of the metabolic syndrome
The developmental origins of the metabolic syndrome
Both epidemiological and clinical evidence suggest relationships between the antenatal environment and the risk of developing insulin resistance and associated cardiovascular disease (part of the metabolic syndrome) in middle age. However, interpretation of these findings has been controversial. Recent experimental observations provide considerable evidence for a causal model linking adaptive responses to early environmental cues and the later risk of disease. Evolutionary and life history theory provide possible explanations of why these phenomena have persisted and how they might cause disease. In this article, we review the clinical and experimental perspectives on the ‘developmental origins of disease’ model in the context of these new concepts.
1043-2760
183-187
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Gluckman, Peter D.
ef2e8b92-0b76-4a12-bd7c-01b0674f94d3
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Gluckman, Peter D. and Hanson, Mark A. (2004) The developmental origins of the metabolic syndrome. Trends in Endocrinology & Metabolism, 15 (4), 183-187. (doi:10.1016/j.tem.2004.03.002).

Record type: Article

Abstract

Both epidemiological and clinical evidence suggest relationships between the antenatal environment and the risk of developing insulin resistance and associated cardiovascular disease (part of the metabolic syndrome) in middle age. However, interpretation of these findings has been controversial. Recent experimental observations provide considerable evidence for a causal model linking adaptive responses to early environmental cues and the later risk of disease. Evolutionary and life history theory provide possible explanations of why these phenomena have persisted and how they might cause disease. In this article, we review the clinical and experimental perspectives on the ‘developmental origins of disease’ model in the context of these new concepts.

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Published date: 2004

Identifiers

Local EPrints ID: 25542
URI: http://eprints.soton.ac.uk/id/eprint/25542
ISSN: 1043-2760
PURE UUID: 44a60935-131c-49cc-8dad-dc0669cc52f7
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 07 Apr 2006
Last modified: 16 Mar 2024 03:17

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Contributors

Author: Peter D. Gluckman
Author: Mark A. Hanson ORCID iD

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