The University of Southampton
University of Southampton Institutional Repository

Life-long echoes: a critical analysis of the developmental origins of adult disease model

Record type: Article

The hypothesis that there is a developmental component to subsequent adult disease initially arose from epidemiological findings relating birth size to either indices of disease risk or actual disease prevalence in later life. While components of the epidemiological analyses have been challenged, there is strong evidence that developmental factors contribute to the later risk of metabolic disease - including insulin resistance, obesity, and heart disease - as well as have a broader impact on osteoporosis, depression and schizophrenia. We suggest that disease risk is greater when there is a mismatch between the early developmental environment (i.e., the phase of developmental plasticity) versus that experienced in mature life (i.e., adulthood), and that nutritional influences are particularly important. It is also critical to distinguish between those factors acting during the developmental phase that disrupt development from those influences that are less extreme and act through regulated processes of epigenetic change. A modelof the relationship between the developmental and mature environment is proposed and suggests interventional strategies that will vary in different population settings.

Full text not available from this repository.

Citation

Gluckman, Peter D., Hanson, Mark A., Morton, Susan M. and Pinal, Catherine S. (2005) Life-long echoes: a critical analysis of the developmental origins of adult disease model Biology of the Neonate, 87, (2), pp. 127-139. (doi:10.1159/000082311).

More information

Published date: 2005
Additional Information: Review Article
Keywords: predictive adaptive response, fetal origins, insulin resistance, evolution

Identifiers

Local EPrints ID: 25544
URI: http://eprints.soton.ac.uk/id/eprint/25544
ISSN: 0006-3126
PURE UUID: 8bee3956-3738-47f5-91f2-be73acd9a45f

Catalogue record

Date deposited: 07 Apr 2006
Last modified: 17 Jul 2017 16:10

Export record

Altmetrics

Contributors

Author: Peter D. Gluckman
Author: Mark A. Hanson
Author: Susan M. Morton
Author: Catherine S. Pinal

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×