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Developmental processes and the induction of cardiovascular function: conceptual aspects

Record type: Article

The epidemiological basis of the developmental origins of disease concept is now widely accepted. The current impetus in research concerns establishing the underlying mechanisms. We discuss the wider biological nature of the phenomenon, with particular reference to ‘maternal effects’, the processes observed in many species by which the mother can induce phenotypic effects in her offspring. Animal models permit investigation of the induction of cardiovascular phenotypic attributes which resemble pathological effects in humans. We discuss the importance of transitions in aspects of the pre- versus the postnatal environment, with emphasis on nutrition and energy expenditure, and the critical role which the timing of environmental cues plays in inducing effects on the offspring. Coupled with the effects of specific maternal dietary components, the effects on the offspring are argued to involve epigenetic mechanisms. In this review we provide a conceptual framework for synthesising experimental and clinical data, important for considering the impact of the developmental origins concept in a life-course approach to the prevention of cardiovascular disease.

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Citation

Hanson, Mark A. and Gluckman, Peter D. (2005) Developmental processes and the induction of cardiovascular function: conceptual aspects The Journal of Physiology, 565, (1), pp. 27-34. (doi:10.1113/jphysiol.2004.082339).

More information

Published date: 2005
Organisations: Dev Origins of Health & Disease

Identifiers

Local EPrints ID: 25585
URI: http://eprints.soton.ac.uk/id/eprint/25585
ISSN: 0022-3751
PURE UUID: f797884c-5e7f-41ee-92c9-1b1b82274ed0

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 17 Jul 2017 16:10

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