Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet
Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet
Fetal adaptations to impaired maternoplacental nutrient supply include altered regional blood flow. Whether such responses operate within the normal range of maternal body composition or diet is unknown, but any change in fetal liver perfusion could alter hepatic development, with long-term consequences for the risk of cardiovascular and metabolic disease. In 381 low-risk pregnancies, we found that the fetuses of slimmer mothers with lower body fat stores and those eating an unbalanced diet had greater liver blood flow and shunted less blood away from the liver through the ductus venosus at 36 weeks gestation. Consequences of such "liver-sparing" may underlie the increased cardiovascular risk of people whose mothers were slimmer and had lower body fat stores in pregnancy.
fetal development, cardiovascular adaptations, liver circulation, maternal nutrition
12-14
Haugen, Guttorm
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Hanson, Mark
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Kiserud, Torvid
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Crozier, Sarah
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Inskip, Hazel
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Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
2005
Haugen, Guttorm
5c251d2a-e757-49b5-bac9-73c15133b927
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Kiserud, Torvid
a7689962-989b-4f84-ae1a-dbc10b57c5f9
Crozier, Sarah
a9c88016-8f46-4659-954e-4d7af8a49594
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Haugen, Guttorm, Hanson, Mark, Kiserud, Torvid, Crozier, Sarah, Inskip, Hazel and Godfrey, Keith M.
(2005)
Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet.
Circulation Research, 96 (1), .
(doi:10.1161/01.RES.0000152391.45273.A2).
Abstract
Fetal adaptations to impaired maternoplacental nutrient supply include altered regional blood flow. Whether such responses operate within the normal range of maternal body composition or diet is unknown, but any change in fetal liver perfusion could alter hepatic development, with long-term consequences for the risk of cardiovascular and metabolic disease. In 381 low-risk pregnancies, we found that the fetuses of slimmer mothers with lower body fat stores and those eating an unbalanced diet had greater liver blood flow and shunted less blood away from the liver through the ductus venosus at 36 weeks gestation. Consequences of such "liver-sparing" may underlie the increased cardiovascular risk of people whose mothers were slimmer and had lower body fat stores in pregnancy.
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Published date: 2005
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Keywords:
fetal development, cardiovascular adaptations, liver circulation, maternal nutrition
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Local EPrints ID: 25601
URI: http://eprints.soton.ac.uk/id/eprint/25601
ISSN: 0009-7330
PURE UUID: 22aad008-a554-47de-8174-92589f5da56f
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Date deposited: 10 Apr 2006
Last modified: 16 Mar 2024 03:17
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Author:
Guttorm Haugen
Author:
Torvid Kiserud
Author:
Sarah Crozier
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