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Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet

Record type: Article

Fetal adaptations to impaired maternoplacental nutrient supply include altered regional blood flow. Whether such responses operate within the normal range of maternal body composition or diet is unknown, but any change in fetal liver perfusion could alter hepatic development, with long-term consequences for the risk of cardiovascular and metabolic disease. In 381 low-risk pregnancies, we found that the fetuses of slimmer mothers with lower body fat stores and those eating an unbalanced diet had greater liver blood flow and shunted less blood away from the liver through the ductus venosus at 36 weeks gestation. Consequences of such "liver-sparing" may underlie the increased cardiovascular risk of people whose mothers were slimmer and had lower body fat stores in pregnancy.

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Citation

Haugen, Guttorm, Hanson, Mark, Kiserud, Torvid, Crozier, Sarah, Inskip, Hazel and Godfrey, Keith M. (2005) Fetal liver-sparing cardiovascular adaptations linked to mother's slimness and diet Circulation Research, 96, (1), pp. 12-14. (doi:10.1161/01.RES.0000152391.45273.A2).

More information

Published date: 2005
Additional Information: Report
Keywords: fetal development, cardiovascular adaptations, liver circulation, maternal nutrition

Identifiers

Local EPrints ID: 25601
URI: http://eprints.soton.ac.uk/id/eprint/25601
ISSN: 0009-7330
PURE UUID: 22aad008-a554-47de-8174-92589f5da56f
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 17 Jul 2017 16:10

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Contributors

Author: Guttorm Haugen
Author: Mark Hanson
Author: Torvid Kiserud
Author: Sarah Crozier
Author: Hazel Inskip ORCID iD

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