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Positron Emission Tomography Compartmental Models

Positron Emission Tomography Compartmental Models
Positron Emission Tomography Compartmental Models
This paper presents theory for compartmental models used in positron emission tomography. Both plasma input models and reference tissue input models are considered. General theory is derived and the systems are characterised in terms of their impulse response functions. The theory shows that the macro parameters of the system may be determined simply from the coefficients of the impulse response functions. These results are discussed in the context of radioligand binding studies. It is shown that binding potential is simply related to the integral of the impulse response functions for all plasma and reference tissue input models currently used in positron emission tomography. The paper also introduces a general compartmental description for the behaviour of the tracer in blood, which then allows for the blood volume induced bias in reference tissue input models to be assessed.
635-652
Gunn, R.N.
e134e55b-3096-4af4-9145-915cc1dcfb08
Gunn, S.R.
306af9b3-a7fa-4381-baf9-5d6a6ec89868
Cunningham, V.J.
6dc44579-200a-4968-925b-0a57f2539abf
Gunn, R.N.
e134e55b-3096-4af4-9145-915cc1dcfb08
Gunn, S.R.
306af9b3-a7fa-4381-baf9-5d6a6ec89868
Cunningham, V.J.
6dc44579-200a-4968-925b-0a57f2539abf

Gunn, R.N., Gunn, S.R. and Cunningham, V.J. (2001) Positron Emission Tomography Compartmental Models. Journal of Cerebral Blood Flow and Metabolism, 21 (6), 635-652.

Record type: Article

Abstract

This paper presents theory for compartmental models used in positron emission tomography. Both plasma input models and reference tissue input models are considered. General theory is derived and the systems are characterised in terms of their impulse response functions. The theory shows that the macro parameters of the system may be determined simply from the coefficients of the impulse response functions. These results are discussed in the context of radioligand binding studies. It is shown that binding potential is simply related to the integral of the impulse response functions for all plasma and reference tissue input models currently used in positron emission tomography. The paper also introduces a general compartmental description for the behaviour of the tracer in blood, which then allows for the blood volume induced bias in reference tissue input models to be assessed.

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Published date: 2001
Additional Information: (Accepted for publication)
Organisations: Electronic & Software Systems

Identifiers

Local EPrints ID: 256086
URI: https://eprints.soton.ac.uk/id/eprint/256086
PURE UUID: cc5e1827-dcf3-4cc3-8e96-ea7ac29bf4e5

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Date deposited: 01 Mar 2005
Last modified: 14 Aug 2019 18:56

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Contributors

Author: R.N. Gunn
Author: S.R. Gunn
Author: V.J. Cunningham

University divisions

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