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Simulation of three-dimensional particle deposition patterns in human lungs and comparison with experimental SPECT data

Record type: Article

To further validate a stochastic particle deposition model, three-dimensional deposition patterns predicted by that model were compared with corresponding spatial particle deposition data obtained from SPECT measurements. In the in vivo inhalation experiments, two different polydisperse aerosols with mass median aerodynamic diameters of 1.6 ? m and 6.8 ? m were inhaled by 12 test subjects, using different nebulizers. Predicted and measured deposition data were compared on three different levels: (1) total lung deposition, (2) deposition per hemispherical shell, and (3) deposition per airway generation.
First, experimental and theoretical total lung deposition data showed good agreement for both the fine (65 ± 9% vs. 55 ± 21%) and the coarse aerosols (55 ± 8% vs. 46 ± 4%).
Second, predicted deposition per hemispherical shell also corresponded well with the experimental data, both exhibiting small deposition fractions in the inner shells and a roughly quadratic increase in the outer shells.
Third, fair agreement was observed for the deposition fractions per airway generation, both experimental data and modelling predictions exhibiting relatively small deposition fractions in central bronchial airway generations, followed by a steep increase in the peripheral respiratory airways. While the overall agreement between measured SPECT data and computed deposition fractions demonstrates that SPECT data can indeed be used for model validation, the current spatial resolution of the SPECT method allows only a limited validation of model predictions at the single airway generation level.

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Citation

Hofmann, W., Sturm, R., Fleming, J., Conway, J. and Bolt, L. (2005) Simulation of three-dimensional particle deposition patterns in human lungs and comparison with experimental SPECT data Aerosol Science and Technology, 39, (8), pp. 771-781. (doi:10.1080/02786820500237158).

More information

Published date: 2005

Identifiers

Local EPrints ID: 25611
URI: http://eprints.soton.ac.uk/id/eprint/25611
ISSN: 0278-6826
PURE UUID: e40ed455-0f9f-42cb-b998-38ad1df87db9
ORCID for J. Conway: ORCID iD orcid.org/0000-0001-6464-1526

Catalogue record

Date deposited: 20 Apr 2006
Last modified: 17 Jul 2017 16:10

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Contributors

Author: W. Hofmann
Author: R. Sturm
Author: J. Fleming
Author: J. Conway ORCID iD
Author: L. Bolt

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