The University of Southampton
University of Southampton Institutional Repository

Aging and physical fitness are more important than obesity in determining exercise-induced generation of GH

Holt, Richard I.G., Webb, Emma, Pentecost, Claire and Sonksen, Peter H. (2001) Aging and physical fitness are more important than obesity in determining exercise-induced generation of GH Journal of Clinical Endocrinology and Metabolism, 86, (12), pp. 5715-5720. (doi:10.1210/jc.86.12.5715).

Record type: Article


Exercise is a potent stimulus for GH secretion. Aging and obesity are associated with a diminution of GH secretion. We wanted to determine whether age or fat mass is more important in regulating the GH response to exercise. Four groups of healthy men were studied: seven lean young men [age, <40 yr; body mass index (BMI), <25 kg/m2], six overweight young men (age, <40 yr; BMI, >27.5), seven lean older men (age, >60 yr; BMI, <25), and 6 overweight older men (age, 60 yr; BMI, >27.5). The men performed a maximal exercise test.
GH secretion was higher in the younger men than in the older men. Peak GH was higher in the older lean men than in the older overweight men. There was no difference between the young groups. Fitness correlated negatively with age and positively with peak GH. In young men, there was no relation between BMI, bioimpedance, or leptin and GH secretion. In contrast, in older men there was an inverse correlation between measures of fat mass and GH secretion.
Age and physical fitness are more important than body fat in regulating exercise-induced GH secretion. These findings have important clinical implications if we are to prevent the frailty and morbidity associated with aging.

PDF 5715.pdf - Version of Record
Restricted to Repository staff only
Download (147kB)

More information

Published date: December 2001


Local EPrints ID: 25614
ISSN: 0021-972X
PURE UUID: a10dfbf8-1fdc-490a-80d6-df13cd28af9b
ORCID for Richard I.G. Holt: ORCID iD

Catalogue record

Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:10

Export record



Author: Emma Webb
Author: Claire Pentecost
Author: Peter H. Sonksen

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.