Fetal programming of the growth hormone-insulin-like growth factor axis
Fetal programming of the growth hormone-insulin-like growth factor axis
Epidemiological studies have shown that small body size at birth and during infancy is associated with increased rates of chronic diseases in adulthood, including cardiovascular disease and osteoporosis. Fetal programming of the growth hormone–insulin-like growth factor (GH–IGF) axis has been proposed as a potential candidate mechanism to explain the link between low birth weight and adult disease. The IGFs and IGF-binding proteins are nutritionally regulated in the fetus and fetal growth retardation leads to abnormalities in the GH–IGF axis. There are also abnormalities in the GH–IGF axis in many of the adult diseases that are associated with low birth weight, including cardiovascular disease and osteoporosis. Finally, there are data from both animals and humans suggesting that programming of the GH–IGF axis might exist.
growth hormone, insulin-like growth factor binding protein, birth weight, osteoporosis, insulin-like growth factor, fetal programming, cardiovascular disease, diabetes
392-397
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
2002
Holt, Richard I.G.
d54202e1-fcf6-4a17-a320-9f32d7024393
Holt, Richard I.G.
(2002)
Fetal programming of the growth hormone-insulin-like growth factor axis.
Trends in Endocrinology & Metabolism, 13 (9), .
(doi:10.1016/S1043-2760(02)00697-5).
Abstract
Epidemiological studies have shown that small body size at birth and during infancy is associated with increased rates of chronic diseases in adulthood, including cardiovascular disease and osteoporosis. Fetal programming of the growth hormone–insulin-like growth factor (GH–IGF) axis has been proposed as a potential candidate mechanism to explain the link between low birth weight and adult disease. The IGFs and IGF-binding proteins are nutritionally regulated in the fetus and fetal growth retardation leads to abnormalities in the GH–IGF axis. There are also abnormalities in the GH–IGF axis in many of the adult diseases that are associated with low birth weight, including cardiovascular disease and osteoporosis. Finally, there are data from both animals and humans suggesting that programming of the GH–IGF axis might exist.
This record has no associated files available for download.
More information
Published date: 2002
Keywords:
growth hormone, insulin-like growth factor binding protein, birth weight, osteoporosis, insulin-like growth factor, fetal programming, cardiovascular disease, diabetes
Identifiers
Local EPrints ID: 25617
URI: http://eprints.soton.ac.uk/id/eprint/25617
ISSN: 1043-2760
PURE UUID: 0fcfdae2-803d-4e3b-b2cc-d4d1097e5e26
Catalogue record
Date deposited: 11 Apr 2006
Last modified: 16 Mar 2024 03:19
Export record
Altmetrics
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
