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Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts

Holt, R.I.G., Syddall, H.E., Phillips, D.I.W., Martyn, C.N., Gluckman, P.D., Breier, B.H., Wood, P.J. and Fall, C.H. (2004) Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts Acta Physiologica Scandinavica, 180, (4), pp. 359-366. (doi:10.1111/j.1365-201X.2004.01262.x).

Record type: Article


Background: Small body size at birth and during infancy is associated with an increased risk of adult osteoporosis and cardiovascular disease. Fetal programming of the growth hormone–insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings.
Aims: To determine whether measurements of GH and IGF-I in late middle age were related to size at birth and in infancy.
Methods: Overnight urinary GH excretion and fasting serum IGF-I were measured in 309 men and 193 women from Hertfordshire (born 1920–1930) for whom birthweight and weight at 1 year were recorded. Serum IGF-I was measured in men and women from Preston (n = 254, born 1935–1943) and Sheffield (n = 215, born 1939–1940) whose birthweight and other birth measurements were recorded.
Results: Urinary GH and serum IGF-I were not related to birthweight, other measurements at birth, or weight at 1 year.
Conclusion: In contrast to previous studies in children or young adults, these data do not support the hypothesis that IGF-I concentrations are programmed by intra-uterine events, as assessed by birthweight, in late middle age.

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Published date: April 2004
Keywords: adult height, birthweight, growth hormone, insulin-like growth factor-i, infancycardiovascular risk-factors, impaired glucose-tolerance, hormone-secretion, adult life, binding-proteins, heart-disease, fetal-growth, elderly-men, igf-i, women


Local EPrints ID: 25630
PURE UUID: f9f4a333-1c6a-4361-8d2a-a47fe394a68d
ORCID for R.I.G. Holt: ORCID iD
ORCID for H.E. Syddall: ORCID iD

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Date deposited: 11 Apr 2006
Last modified: 17 Jul 2017 16:10

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Author: R.I.G. Holt ORCID iD
Author: H.E. Syddall ORCID iD
Author: D.I.W. Phillips
Author: C.N. Martyn
Author: P.D. Gluckman
Author: B.H. Breier
Author: P.J. Wood
Author: C.H. Fall

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