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Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: results from the European Prospective Osteoporosis Study

Ismail, A.A., Cockerill, W., Cooper, C., Finn, J.D., Abendroth, K., Parisi, G., Banzer, D., Benevolenskaya, L.I., Bhalla, A.K., Armas, J.B., Cannata, J.B., Delmas, P.D., Dequeker, J., Dilsen, G., Eastell, R., Ershova, O., Falch, J.A., Felsch, B., Havelka, S., Hoszowski, K., Jajic, I., Kragl, U., Johnell, O., Lopez Vaz, A., Lorenc, R., Lyritis, G.F., Masaryk, P., Matthis, C., Miazgowski, T., Pols, H.A., Poor, G., Rapado, A., Raspe, H.H., Reid, D.M., Reisinger, W., Janott, J., Scheidt-Nave, C., Stepan, J., Todd, C., Weber, K., Woolf, A.D., Ambrecht, G., Gowin, W., Felsenberg, D., Lunt, M., Kanis, J.A., Reeve, J., Silman, A.J. and O'Neill, T.W. (2001) Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: results from the European Prospective Osteoporosis Study Osteoporosis International, 12, (2), pp. 85-90. (doi:10.1007/s001980170138).

Record type: Article


The presence of a vertebral deformity increases the risk of subsequent spinal deformities. The aim of this analysis was to determine whether the presence of vertebral deformity predicts incident hip and other limb fractures. Six thousand three hundred and forty-four men and 6788 women aged 50 years and over were recruited from population registers in 31 European centers and followed prospectively for a median of 3 years.
All subjects had radiographs performed at baseline and the presence of vertebral deformity was assessed using established morphometric methods. Incident limb fractures which occurred during the follow- up period were ascertained by annual postal questionnaire and confirmed by radiographs, review of medical records and personal interview.
During a total of 40 348 person-years of follow-up, 138 men and 391 women sustained a limb fracture. Amongst the women, after adjustment for age, prevalent vertebral deformity was a strong predictor of incident hip fracture, (rate ratio (RR) = 4.5; 95% CI 2.1-9.4) and a weak predictor of 'other' limb fractures (RR = 1.6; 95% CI 1.1-2.4), though not distal forearm fracture (RR = 1.0; 95% CI 0.6-1.6). The predictive risk increased with increasing number of prevalent deformities, particularly for subsequent hip fracture: for two or more deformities, RR = 7.2 (95% CI 3.0-17.3). Amongst men, vertebral deformity was not associated with an increased risk of incident limb fracture though there was a nonsignificant trend toward an increased risk of hip fracture with increasing number of deformities. In summary, prevalent radiographic vertebral deformities in women are a strong predictor of hip fracture, and to a lesser extent humerus and 'other' limb fractures; however, they do not predict distal forearm fractures.

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Published date: 2001
Keywords: incidence, limb fracture, osteoporosis, vertebral deformity, vertebral osteoporosis


Local EPrints ID: 25648
ISSN: 0937-941X
PURE UUID: 463eda4c-5f3c-450f-902b-ebb23cf45e31
ORCID for C. Cooper: ORCID iD

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Date deposited: 20 Apr 2006
Last modified: 17 Jul 2017 16:09

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Author: A.A. Ismail
Author: W. Cockerill
Author: C. Cooper ORCID iD
Author: J.D. Finn
Author: K. Abendroth
Author: G. Parisi
Author: D. Banzer
Author: L.I. Benevolenskaya
Author: A.K. Bhalla
Author: J.B. Armas
Author: J.B. Cannata
Author: P.D. Delmas
Author: J. Dequeker
Author: G. Dilsen
Author: R. Eastell
Author: O. Ershova
Author: J.A. Falch
Author: B. Felsch
Author: S. Havelka
Author: K. Hoszowski
Author: I. Jajic
Author: U. Kragl
Author: O. Johnell
Author: A. Lopez Vaz
Author: R. Lorenc
Author: G.F. Lyritis
Author: P. Masaryk
Author: C. Matthis
Author: T. Miazgowski
Author: H.A. Pols
Author: G. Poor
Author: A. Rapado
Author: H.H. Raspe
Author: D.M. Reid
Author: W. Reisinger
Author: J. Janott
Author: C. Scheidt-Nave
Author: J. Stepan
Author: C. Todd
Author: K. Weber
Author: A.D. Woolf
Author: G. Ambrecht
Author: W. Gowin
Author: D. Felsenberg
Author: M. Lunt
Author: J.A. Kanis
Author: J. Reeve
Author: A.J. Silman
Author: T.W. O'Neill

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