The University of Southampton
University of Southampton Institutional Repository

Comparison of calcaneal ultrasound and DXA to assess the risk of corticosteroid-induced osteoporosis: a cross-sectional study

Record type: Article

Patients on long-term oral corticosteroids have an increased risk of low bone mass and fragility fractures. Fracture risk rises soon after commencement of corticosteroid therapy and it is possible that these agents adversely influence bone architecture disproportionately to their effect on bone mass. The best means of assessing bone status in patients using corticosteroids remains uncertain, but quantitative ultrasound of the calcaneus may provide evidence of microarchitectural changes not detected by dual-energy X-ray absorptiometry (DXA). Patients with Crohn's disease have an increased risk of low bone mineral density (BMD), the etiology of which is multifactorial but includes corticosteroid use. We studied 118 consecutive patients with Crohn's disease, 21 of whom used continuous oral corticosteroids, 70 of whom were intermittent users, and 27 who had never used the drug. All patients received DXA of the lumbar spine, hip and calcaneus and quantitative ultrasound (QUS) of the calcaneus. The different techniques were compared using a femoral neck T-score hm1.5 as the threshold of corticosteroid-induced osteoporosis. When compared with the femoral neck T-score, there were no significant differences between the predictive values of lumbar spine DXA, calcaneal DXA or calcaneal QUS to identify low femoral neck BMD. However, the absolute T-score required to give similar discriminatory capacity to femoral neck T-score varied substantially (T = m0.81 to m1.5) between the different measurement techniques and sites.

Full text not available from this repository.

Citation

Javaid, M.K., McCrudden, P.R., Taylor, P., Petley, G.W., Stroud, M., Fine, D.R., Cooper, C. and Arden, N.K. (2001) Comparison of calcaneal ultrasound and DXA to assess the risk of corticosteroid-induced osteoporosis: a cross-sectional study Osteoporosis International, 12, (9), pp. 788-793. (doi:10.1007/s001980170056).

More information

Published date: 2001
Keywords: calcaneal dxa, calcaneal us, crohn's disease, inflammatory bowel disease, osteoporosis

Identifiers

Local EPrints ID: 25663
URI: http://eprints.soton.ac.uk/id/eprint/25663
ISSN: 0937-941X
PURE UUID: 5afc2da3-2203-49f4-96a4-326a440ceec5
ORCID for G.W. Petley: ORCID iD orcid.org/0000-0002-3295-0444

Catalogue record

Date deposited: 11 Apr 2006
Last modified: 17 Jul 2017 16:09

Export record

Altmetrics


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×