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Gender-linked hypertension in offspring of lard-fed pregnant rats

Gender-linked hypertension in offspring of lard-fed pregnant rats
Gender-linked hypertension in offspring of lard-fed pregnant rats
Epidemiological studies suggest an association between maternal nutrition and offspring cardiovascular disease. We previously demonstrated endothelial dysfunction and abnormal aortic fatty acid composition in adult female offspring of rats fed animal lard during pregnancy. We have now further investigated this model. Female Sprague-Dawley rats were fed a control breeding diet (5.3% fat) or a diet rich in lard (25.7% fat) 10 days before and throughout pregnancy and lactation. Male and female offspring were implanted with radiotelemeters for recording of blood pressure, heart rate, and activity at 80, 180, and 360 days of age. Reactivity to acetylcholine and to nitric oxide were assessed in isolated small mesenteric arteries from 80- and 180-day-old littermates. Systolic blood pressure (awake phase) was raised in female offspring (180 days: offspring of control, 130.7±1.6 mm Hg, n=5, versus offspring of lard-fed, 138.1±2.9, n=5, P=0.029; 360 days: offspring of control, 129.7±3.7 mm Hg, n=6, versus offspring of lard-fed, 142.1±3.2, n=6, P=0.005). Diastolic blood pressure was also raised at 180 days (offspring of control, 87.6±1.0 mm Hg, n=5, versus offspring of lard-fed, 94.7±2.6, n=5, P=0.011). Blood pressure was not raised in male offspring. Endothelium-dependent relaxation to acetylcholine was blunted in male and female offspring of lard-fed dams (80 and 180 days). Feeding a diet rich in lard to pregnant rats leads to gender-related cardiovascular dysfunction in normally fed offspring.
pregnancy, rats, diet, blood pressure, endothelium
0194-911X
168-175
Khan, Imran Y.
eff572bd-c9a9-4ae3-b343-dc726e84764a
Taylor, Paul D.
43ab99bd-30b7-401a-892e-54d9c7fada15
Dekou, Vasia
751a411d-c3d8-4837-bca0-af1219d6e692
Seed, Paul T.
d3eda3f4-0e4c-4c17-9efd-dc75b583e79a
Lakasing, Lorin
b14ac90d-58c5-47be-beae-465db3a66402
Graham, Delyth
b79375bc-afe7-4f37-84ab-e1c48f702d28
Dominiczak, Anna F.
87c143c0-d649-4ef8-a705-2fbeeeffcc91
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Khan, Imran Y.
eff572bd-c9a9-4ae3-b343-dc726e84764a
Taylor, Paul D.
43ab99bd-30b7-401a-892e-54d9c7fada15
Dekou, Vasia
751a411d-c3d8-4837-bca0-af1219d6e692
Seed, Paul T.
d3eda3f4-0e4c-4c17-9efd-dc75b583e79a
Lakasing, Lorin
b14ac90d-58c5-47be-beae-465db3a66402
Graham, Delyth
b79375bc-afe7-4f37-84ab-e1c48f702d28
Dominiczak, Anna F.
87c143c0-d649-4ef8-a705-2fbeeeffcc91
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f

Khan, Imran Y., Taylor, Paul D., Dekou, Vasia, Seed, Paul T., Lakasing, Lorin, Graham, Delyth, Dominiczak, Anna F., Hanson, Mark A. and Poston, Lucilla (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension, 41 (1), 168-175. (doi:10.1161/01.HYP.0000047511.97879.FC).

Record type: Article

Abstract

Epidemiological studies suggest an association between maternal nutrition and offspring cardiovascular disease. We previously demonstrated endothelial dysfunction and abnormal aortic fatty acid composition in adult female offspring of rats fed animal lard during pregnancy. We have now further investigated this model. Female Sprague-Dawley rats were fed a control breeding diet (5.3% fat) or a diet rich in lard (25.7% fat) 10 days before and throughout pregnancy and lactation. Male and female offspring were implanted with radiotelemeters for recording of blood pressure, heart rate, and activity at 80, 180, and 360 days of age. Reactivity to acetylcholine and to nitric oxide were assessed in isolated small mesenteric arteries from 80- and 180-day-old littermates. Systolic blood pressure (awake phase) was raised in female offspring (180 days: offspring of control, 130.7±1.6 mm Hg, n=5, versus offspring of lard-fed, 138.1±2.9, n=5, P=0.029; 360 days: offspring of control, 129.7±3.7 mm Hg, n=6, versus offspring of lard-fed, 142.1±3.2, n=6, P=0.005). Diastolic blood pressure was also raised at 180 days (offspring of control, 87.6±1.0 mm Hg, n=5, versus offspring of lard-fed, 94.7±2.6, n=5, P=0.011). Blood pressure was not raised in male offspring. Endothelium-dependent relaxation to acetylcholine was blunted in male and female offspring of lard-fed dams (80 and 180 days). Feeding a diet rich in lard to pregnant rats leads to gender-related cardiovascular dysfunction in normally fed offspring.

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Published date: 2003
Keywords: pregnancy, rats, diet, blood pressure, endothelium

Identifiers

Local EPrints ID: 25719
URI: http://eprints.soton.ac.uk/id/eprint/25719
ISSN: 0194-911X
PURE UUID: 3dcda8bc-1c52-4039-b880-5f745f2c7b9b
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 21 Apr 2006
Last modified: 16 Mar 2024 03:17

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Contributors

Author: Imran Y. Khan
Author: Paul D. Taylor
Author: Vasia Dekou
Author: Paul T. Seed
Author: Lorin Lakasing
Author: Delyth Graham
Author: Anna F. Dominiczak
Author: Mark A. Hanson ORCID iD
Author: Lucilla Poston

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