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Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function

Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function
Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function
Objective: Previous studies in humans and animals have suggested that undernutrition in utero and in early post-natal life may lead to altered vascular function in a number of peripheral arteries. We investigated the effect of pre- and post-natal nutrient restriction on the vascular reactivity of the left internal thoracic artery using a sheep model.
Methods: Welsh mountain ewes were mated and assigned to three dietary groups: (1) 100% of total nutritional requirements (control, n = 6); (2) 50% of total nutritional requirements during the first 31 days of gestation (n = 6); and (3) 50% nutritional restriction during the first 31 days of gestation, followed by a restriction in the diet of their offspring 12–25 weeks post-natally, designed to produce a 15% reduction in growth trajectory (n = 7). The male offspring were sacrificed at 130 weeks; the left internal thoracic artery was mounted onto a wire myograph and the reactivity of the vessel to various agonists measured.
Results: The offspring of animals who underwent an early gestation nutrient restriction had a significantly increased basal tone (0.41 ± 0.25 vs 6.34 ± 1.35, p = 0.015) and sensitivity to phenylephrine (log EC50: ?6.23 ± 0.04 M vs ?5.74 ± 0.17 M, p = 0.036) as compared with control animals. However, this phenomenon was not seen in animals that underwent both pre- and post-natal nutrient restriction.
Conclusions: Pre-natal undernutrition increases the basal tone and sensitivity of the left internal thoracic artery to phenylephrine. This effect is significantly attenuated by continued undernutrition in early post-natal life. These experiments suggest that in utero and early post-natal undernutrition may be important determinants of graft function in later life.
coronary artery bypass conduits, vascular tone and reactivity
1010-7940
811-815
Khan, Omar A.
e6bbb536-9991-48be-a54d-4fbce6284238
Torrens, Christopher
15a35713-0651-4249-8227-5901e2cfcd22
Noakes, David E.
d7f0b55e-8a82-4285-9b75-85f5aec6db8c
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Green, Lucy R.
8a601974-efe5-4916-9268-9e7bc72d89c5
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Khan, Omar A.
e6bbb536-9991-48be-a54d-4fbce6284238
Torrens, Christopher
15a35713-0651-4249-8227-5901e2cfcd22
Noakes, David E.
d7f0b55e-8a82-4285-9b75-85f5aec6db8c
Poston, Lucilla
916aced2-462e-445f-9efa-83ed4b7b3a9f
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Green, Lucy R.
8a601974-efe5-4916-9268-9e7bc72d89c5
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c

Khan, Omar A., Torrens, Christopher, Noakes, David E., Poston, Lucilla, Hanson, Mark A., Green, Lucy R. and Ohri, Sunil K. (2005) Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function. European Journal of Cardio-thoracic Surgery, 28 (6), 811-815. (doi:10.1016/j.ejcts.2005.08.021).

Record type: Article

Abstract

Objective: Previous studies in humans and animals have suggested that undernutrition in utero and in early post-natal life may lead to altered vascular function in a number of peripheral arteries. We investigated the effect of pre- and post-natal nutrient restriction on the vascular reactivity of the left internal thoracic artery using a sheep model.
Methods: Welsh mountain ewes were mated and assigned to three dietary groups: (1) 100% of total nutritional requirements (control, n = 6); (2) 50% of total nutritional requirements during the first 31 days of gestation (n = 6); and (3) 50% nutritional restriction during the first 31 days of gestation, followed by a restriction in the diet of their offspring 12–25 weeks post-natally, designed to produce a 15% reduction in growth trajectory (n = 7). The male offspring were sacrificed at 130 weeks; the left internal thoracic artery was mounted onto a wire myograph and the reactivity of the vessel to various agonists measured.
Results: The offspring of animals who underwent an early gestation nutrient restriction had a significantly increased basal tone (0.41 ± 0.25 vs 6.34 ± 1.35, p = 0.015) and sensitivity to phenylephrine (log EC50: ?6.23 ± 0.04 M vs ?5.74 ± 0.17 M, p = 0.036) as compared with control animals. However, this phenomenon was not seen in animals that underwent both pre- and post-natal nutrient restriction.
Conclusions: Pre-natal undernutrition increases the basal tone and sensitivity of the left internal thoracic artery to phenylephrine. This effect is significantly attenuated by continued undernutrition in early post-natal life. These experiments suggest that in utero and early post-natal undernutrition may be important determinants of graft function in later life.

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More information

Published date: December 2005
Keywords: coronary artery bypass conduits, vascular tone and reactivity

Identifiers

Local EPrints ID: 25721
URI: http://eprints.soton.ac.uk/id/eprint/25721
ISSN: 1010-7940
PURE UUID: 17ab79fd-d638-4eca-ad1a-8c2cf90731ea
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X
ORCID for Lucy R. Green: ORCID iD orcid.org/0000-0001-7423-9696

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 16 Mar 2024 03:19

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Contributors

Author: Omar A. Khan
Author: Christopher Torrens
Author: David E. Noakes
Author: Lucilla Poston
Author: Mark A. Hanson ORCID iD
Author: Lucy R. Green ORCID iD
Author: Sunil K. Ohri

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