The University of Southampton
University of Southampton Institutional Repository

Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function

Record type: Article

Objective: Previous studies in humans and animals have suggested that undernutrition in utero and in early post-natal life may lead to altered vascular function in a number of peripheral arteries. We investigated the effect of pre- and post-natal nutrient restriction on the vascular reactivity of the left internal thoracic artery using a sheep model.
Methods: Welsh mountain ewes were mated and assigned to three dietary groups: (1) 100% of total nutritional requirements (control, n = 6); (2) 50% of total nutritional requirements during the first 31 days of gestation (n = 6); and (3) 50% nutritional restriction during the first 31 days of gestation, followed by a restriction in the diet of their offspring 12–25 weeks post-natally, designed to produce a 15% reduction in growth trajectory (n = 7). The male offspring were sacrificed at 130 weeks; the left internal thoracic artery was mounted onto a wire myograph and the reactivity of the vessel to various agonists measured.
Results: The offspring of animals who underwent an early gestation nutrient restriction had a significantly increased basal tone (0.41 ± 0.25 vs 6.34 ± 1.35, p = 0.015) and sensitivity to phenylephrine (log EC50: ?6.23 ± 0.04 M vs ?5.74 ± 0.17 M, p = 0.036) as compared with control animals. However, this phenomenon was not seen in animals that underwent both pre- and post-natal nutrient restriction.
Conclusions: Pre-natal undernutrition increases the basal tone and sensitivity of the left internal thoracic artery to phenylephrine. This effect is significantly attenuated by continued undernutrition in early post-natal life. These experiments suggest that in utero and early post-natal undernutrition may be important determinants of graft function in later life.

Full text not available from this repository.

Citation

Khan, Omar A., Torrens, Christopher, Noakes, David E., Poston, Lucilla, Hanson, Mark A., Green, Lucy R. and Ohri, Sunil K. (2005) Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function European Journal of Cardio-Thoracic Surgery, 28, (6), pp. 811-815. (doi:10.1016/j.ejcts.2005.08.021).

More information

Published date: December 2005
Keywords: coronary artery bypass conduits, vascular tone and reactivity

Identifiers

Local EPrints ID: 25721
URI: http://eprints.soton.ac.uk/id/eprint/25721
ISSN: 1010-7940
PURE UUID: 17ab79fd-d638-4eca-ad1a-8c2cf90731ea
ORCID for Lucy R. Green: ORCID iD orcid.org/0000-0001-7423-9696

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 17 Jul 2017 16:09

Export record

Altmetrics

Contributors

Author: Omar A. Khan
Author: David E. Noakes
Author: Lucilla Poston
Author: Mark A. Hanson
Author: Lucy R. Green ORCID iD
Author: Sunil K. Ohri

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×