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Fetal origins of coronary heart disease-implications for cardiothoracic surgery?

Fetal origins of coronary heart disease-implications for cardiothoracic surgery?
Fetal origins of coronary heart disease-implications for cardiothoracic surgery?
Over the last 15 years, there has been growing evidence that poor nutrition during gestation plays an important role in the development of coronary heart disease. This hypothesis, commonly known as the ‘fetal origins of adult disease’ has now gained widespread acceptance in the scientific community. In this review, we discuss the evidence for this theory and analyse the patho-physiological mechanisms underlying the relationship between altered fetal growth and coronary heart disease. Finally, the potential relevance of the theory to cardiac surgical practice will be evaluated.
coronary heart disease, fetal, undernutrition
1010-7940
1036-1042
Khan, Omar A.
e6bbb536-9991-48be-a54d-4fbce6284238
Chau, Ryan
f70dbfbc-da5e-4482-8627-c415ad6fdb70
Bertram, Caroline E.
7cf2f298-1d96-4966-85e5-1f41806905e2
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c
Khan, Omar A.
e6bbb536-9991-48be-a54d-4fbce6284238
Chau, Ryan
f70dbfbc-da5e-4482-8627-c415ad6fdb70
Bertram, Caroline E.
7cf2f298-1d96-4966-85e5-1f41806905e2
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Ohri, Sunil K.
8aa5698c-78cf-4f59-a5af-5afa46f0348c

Khan, Omar A., Chau, Ryan, Bertram, Caroline E., Hanson, Mark A. and Ohri, Sunil K. (2005) Fetal origins of coronary heart disease-implications for cardiothoracic surgery? European Journal of Cardio-thoracic Surgery, 27 (6), 1036-1042. (doi:10.1016/j.ejcts.2005.01.032).

Record type: Article

Abstract

Over the last 15 years, there has been growing evidence that poor nutrition during gestation plays an important role in the development of coronary heart disease. This hypothesis, commonly known as the ‘fetal origins of adult disease’ has now gained widespread acceptance in the scientific community. In this review, we discuss the evidence for this theory and analyse the patho-physiological mechanisms underlying the relationship between altered fetal growth and coronary heart disease. Finally, the potential relevance of the theory to cardiac surgical practice will be evaluated.

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Published date: 2005
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Keywords: coronary heart disease, fetal, undernutrition

Identifiers

Local EPrints ID: 25722
URI: http://eprints.soton.ac.uk/id/eprint/25722
DOI: doi:10.1016/j.ejcts.2005.01.032
ISSN: 1010-7940
PURE UUID: 175f1c2a-a8eb-4a85-aa01-1f74243f3713
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 16 Mar 2024 03:17

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Contributors

Author: Omar A. Khan
Author: Ryan Chau
Author: Caroline E. Bertram
Author: Mark A. Hanson ORCID iD
Author: Sunil K. Ohri

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