Influence of LRP5 polymorphisms on normal variation in BMD
Influence of LRP5 polymorphisms on normal variation in BMD
Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.
1619-1627
Koay, M. Audrey
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Woon, Peng Y.
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Zhang, Yun
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Miles, Lisa J.
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Duncan, Emma L.
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Ralston, Stuart H.
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Compston, Juliet E.
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Cooper, Cyrus
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Keen, Ricahrd
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Langdahl, Bente L.
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MacLelland, Alasdair
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O'Riordan, Jeffrey
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Pols, Huibert A.
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Reid, David M.
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Uitterlinden, Andrew G.
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Wass, John A.H.
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Brown, Matthew A.
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2004
Koay, M. Audrey
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Woon, Peng Y.
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Zhang, Yun
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Miles, Lisa J.
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Duncan, Emma L.
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Ralston, Stuart H.
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Compston, Juliet E.
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Cooper, Cyrus
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Keen, Ricahrd
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Langdahl, Bente L.
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MacLelland, Alasdair
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O'Riordan, Jeffrey
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Pols, Huibert A.
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Reid, David M.
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Uitterlinden, Andrew G.
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Wass, John A.H.
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Brown, Matthew A.
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Koay, M. Audrey, Woon, Peng Y., Zhang, Yun, Miles, Lisa J., Duncan, Emma L., Ralston, Stuart H., Compston, Juliet E., Cooper, Cyrus, Keen, Ricahrd, Langdahl, Bente L., MacLelland, Alasdair, O'Riordan, Jeffrey, Pols, Huibert A., Reid, David M., Uitterlinden, Andrew G., Wass, John A.H. and Brown, Matthew A.
(2004)
Influence of LRP5 polymorphisms on normal variation in BMD.
Journal of Bone and Mineral Research, 19 (10), .
(doi:10.1359/JBMR.040704).
Abstract
Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.
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Published date: 2004
Identifiers
Local EPrints ID: 25726
URI: http://eprints.soton.ac.uk/id/eprint/25726
ISSN: 0884-0431
PURE UUID: 43f9844e-6186-4599-899f-f6dd59fce6fd
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Date deposited: 10 Apr 2006
Last modified: 18 Mar 2024 02:44
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Contributors
Author:
M. Audrey Koay
Author:
Peng Y. Woon
Author:
Yun Zhang
Author:
Lisa J. Miles
Author:
Emma L. Duncan
Author:
Stuart H. Ralston
Author:
Juliet E. Compston
Author:
Ricahrd Keen
Author:
Bente L. Langdahl
Author:
Alasdair MacLelland
Author:
Jeffrey O'Riordan
Author:
Huibert A. Pols
Author:
David M. Reid
Author:
Andrew G. Uitterlinden
Author:
John A.H. Wass
Author:
Matthew A. Brown
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