The University of Southampton
University of Southampton Institutional Repository

Body size at birth and blood pressure among children in developing countries

Record type: Article

Background: studies in developed countries have shown that reduced fetal growth is related to raised blood pressure in childhood and adult life. Little is known about this association in developing countries, where fetal growth retardation is common.
Methods: in 1994–1995, we measured blood pressure in 1570 3–6-year-old children living in China, Guatemala, Chile, Nigeria and Sweden. We related their blood pressure to patterns of fetal growth, as measured by body proportions at birth. The children were all born after 37 weeks gestation and weighed more than 2.5 kg at birth.
Results: in each country, blood pressure was positively related to the child's current weight. After adjusting for this and gender, systolic pressure was inversely related to size at birth in all countries except Nigeria. In Chile, China and Guatemala, children who were proportionately small at birth had raised systolic pressure. For example, in Chile, systolic pressure adjusted for current weight increased by 4.9 mmHg (95% CI : 2.1, 7.7) for every kilogram decrease in birthweight, by 1 mmHg (95% CI : 0.4, 1.6) for every centimetre decrease in birth length, and by 1.3 mmHg (95% CI : 0.4, 2.2) for every centimetre decrease in head circumference at birth. In Sweden, systolic pressure was higher in children who were disproportionately small, that is thin, at birth. Systolic pressure increased by 0.3 mmHg (95% CI : 0.0, 0.6) for every unit (kg/m3) decrease in ponderal index at birth. These associations were independent of the duration of gestation.
Conclusions: raised blood pressure among children in three samples from China, Central and South America is related to proportionate reduction in body size at birth, which results from reduced growth throughout gestation. The relation between fetal growth and blood pressure may be different in African populations. Proportionately reduced fetal growth is the prevalent pattern of fetal growth retardation in developing countries, and is associated with chronic undernutrition among women. Improvement in the nutrition and health of girls and young women may be important in preventing cardiovascular disease in developing countries.

Full text not available from this repository.

Citation

Law, C.M., Egger, P., Dada, O., Delgado, H., Kylberg, E., Lavin, P., Tang, G H., Von Hertzen, H., Shiell, A.W. and Barker, D.J.P. (2001) Body size at birth and blood pressure among children in developing countries International Journal of Epidemiology, 30, (1), pp. 52-57. (doi:10.1093/ije/30.1.52).

More information

Published date: 2001
Keywords: blood pressure, population, pregnancy, epidemiology

Identifiers

Local EPrints ID: 25745
URI: http://eprints.soton.ac.uk/id/eprint/25745
ISSN: 0300-5771
PURE UUID: 3b9c82b0-6269-4b2b-a7b5-cc06ed16fdf6

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 17 Jul 2017 16:09

Export record

Altmetrics

Contributors

Author: C.M. Law
Author: P. Egger
Author: O. Dada
Author: H. Delgado
Author: E. Kylberg
Author: P. Lavin
Author: G H. Tang
Author: H. Von Hertzen
Author: A.W. Shiell
Author: D.J.P. Barker

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×