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Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age

Law, C.M., Shiell, A.W., Newsome, C.A., Syddall, H.E., Shinebourne, E.A., Fayers, P.M., Martyn, C.N. and De Swiet, M. (2002) Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age Circulation, 105, (9), pp. 1088-1092. (doi:10.1161/hc0902.104677).

Record type: Article


Background: people who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure.
Methods and Results: we studied blood pressure in 346 British men and women aged 22 years whose size had been measured at birth and for the first 10 years of life. Their childhood growth was characterized using a conditional method that, free from the effect of regression to the mean, estimated catch-up growth. People who had been small at birth but who gained weight rapidly during early childhood (1 to 5 years) had the highest adult blood pressures. Systolic pressure increased by 1.3 mm Hg (95% CI, 0.3 to 2.3) for every standard deviation score decrease in birth weight and, independently, increased by 1.6 mm Hg (95% CI, 0.6 to 2.7) for every standard deviation score increase in early childhood weight gain. Adjustment for adult body mass index attenuated the effect of early childhood weight gain but not of birth weight. Relationships were smaller for diastolic pressure. Weight gain in the first year of life did not influence adult blood pressure.
Conclusions: part of the risk of adult hypertension is set in fetal life. Accelerated weight gain in early childhood adds to this risk, which is partly mediated through the prediction of adult fatness. The primary prevention of hypertension may depend on strategies that promote fetal growth and reduce childhood obesity.

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Published date: 2002
Keywords: blood pressure, obesity, pediatrics, birth weight, prevention


Local EPrints ID: 25747
ISSN: 0009-7322
PURE UUID: ffe4f6a3-5251-4048-9e6a-a9a41898c8e7
ORCID for H.E. Syddall: ORCID iD

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Date deposited: 10 Apr 2006
Last modified: 17 Jul 2017 16:09

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Author: C.M. Law
Author: A.W. Shiell
Author: C.A. Newsome
Author: H.E. Syddall ORCID iD
Author: E.A. Shinebourne
Author: P.M. Fayers
Author: C.N. Martyn
Author: M. De Swiet

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