The University of Southampton
University of Southampton Institutional Repository

Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age

Law, C.M., Shiell, A.W., Newsome, C.A., Syddall, H.E., Shinebourne, E.A., Fayers, P.M., Martyn, C.N. and De Swiet, M. (2002) Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age Circulation, 105, (9), pp. 1088-1092. (doi:10.1161/hc0902.104677).

Record type: Article

Abstract

Background: people who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure.
Methods and Results: we studied blood pressure in 346 British men and women aged 22 years whose size had been measured at birth and for the first 10 years of life. Their childhood growth was characterized using a conditional method that, free from the effect of regression to the mean, estimated catch-up growth. People who had been small at birth but who gained weight rapidly during early childhood (1 to 5 years) had the highest adult blood pressures. Systolic pressure increased by 1.3 mm Hg (95% CI, 0.3 to 2.3) for every standard deviation score decrease in birth weight and, independently, increased by 1.6 mm Hg (95% CI, 0.6 to 2.7) for every standard deviation score increase in early childhood weight gain. Adjustment for adult body mass index attenuated the effect of early childhood weight gain but not of birth weight. Relationships were smaller for diastolic pressure. Weight gain in the first year of life did not influence adult blood pressure.
Conclusions: part of the risk of adult hypertension is set in fetal life. Accelerated weight gain in early childhood adds to this risk, which is partly mediated through the prediction of adult fatness. The primary prevention of hypertension may depend on strategies that promote fetal growth and reduce childhood obesity.

Full text not available from this repository.

More information

Published date: 2002
Keywords: blood pressure, obesity, pediatrics, birth weight, prevention

Identifiers

Local EPrints ID: 25747
URI: http://eprints.soton.ac.uk/id/eprint/25747
ISSN: 0009-7322
PURE UUID: ffe4f6a3-5251-4048-9e6a-a9a41898c8e7
ORCID for H.E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306

Catalogue record

Date deposited: 10 Apr 2006
Last modified: 17 Jul 2017 16:09

Export record

Altmetrics

Contributors

Author: C.M. Law
Author: A.W. Shiell
Author: C.A. Newsome
Author: H.E. Syddall ORCID iD
Author: E.A. Shinebourne
Author: P.M. Fayers
Author: C.N. Martyn
Author: M. De Swiet

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×