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Risk of new vertebral fracture in the year following a fracture

Lindsay, Robert, Silverman, Stuart L., Cooper, Cyrus, Hanley, David A., Barton, Ian, Broy, Susan B., Licata, Angelo, Benhamou, Laurent, Geusens, Piet, Flowers, Kirsten, Stracke, Hilmar and Seeman, Ego (2001) Risk of new vertebral fracture in the year following a fracture JAMA: The Journal of the American Medical Association, 285, (3), pp. 320-323. (doi:10.1001/jama.285.3.320).

Record type: Article


Context: Vertebral fractures significantly increase lifetime risk of future fractures, but risk of further vertebral fractures in the period immediately following a vertebral fracture has not been evaluated.
Objective: To determine the incidence of further vertebral fracture in the year following a vertebral fracture.
Design and Setting: Analysis of data from 4 large 3-year osteoporosis treatment trials conducted at 373 study centers in North America, Europe, Australia, and New Zealand from November 1993 to April 1998.
Subjects: Postmenopausal women who had been randomized to a placebo group and for whom vertebral fracture status was known at entry (n = 2725).
Main Outcome Measure: Occurrence of radiographically identified vertebral fracture during the year following an incident vertebral fracture.
Results: Subjects were a mean age of 74 years and had a mean of 28 years since menopause. The cumulative incidence of new vertebral fractures in the first year was 6.6%. Presence of 1 or more vertebral fractures at baseline increased risk of sustaining a vertebral fracture by 5-fold during the initial year of the study compared with the incidence in subjects without prevalent vertebral fractures at baseline (relative risk [RR], 5.1; 95% confidence interval [CI], 3.1-8.4; P<.001). Among the 381 participants who developed an incident vertebral fracture, the incidence of a new vertebral fracture in the subsequent year was 19.2% (95% CI, 13.6%-24.8%). This risk was also increased in the presence of prevalent vertebral fractures (RR, 9.3; 95% CI, 1.2-71.6; P = .03).
Conclusion: Our data indicate that women who develop a vertebral fracture are at substantial risk for additional fracture within the next year.

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Published date: 17 January 2001
Organisations: Dev Origins of Health & Disease


Local EPrints ID: 25762
ISSN: 0098-7484
PURE UUID: bf4726da-e25b-4673-8252-1a5e9611e238
ORCID for Cyrus Cooper: ORCID iD

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Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:09

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Author: Robert Lindsay
Author: Stuart L. Silverman
Author: Cyrus Cooper ORCID iD
Author: David A. Hanley
Author: Ian Barton
Author: Susan B. Broy
Author: Angelo Licata
Author: Laurent Benhamou
Author: Piet Geusens
Author: Kirsten Flowers
Author: Hilmar Stracke
Author: Ego Seeman

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