The University of Southampton
University of Southampton Institutional Repository

The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring

Loos, Ruth J.F., Phillips, David I.W., Fagard, Robert, Beunen, Gaston, Derom, Catherine, Mathieu, Chantal, Verhaeghe, Johan and Vlietinck, Robert (2002) The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring Diabetes Care, 25, (12), pp. 2191-2196. (doi:10.2337/diacare.25.12.2191).

Record type: Article

Abstract

Objective: There is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults. We have carried out a twin study to distinguish among maternal influences, which affect both twins; fetoplacental influences, which are unique to each twin; and the genetic factors that may underlie this association.
Research Design and Methods: We identified a sample of 423 twin pairs (250 monozygotic and 173 dizygotic) from the East Flanders Prospective Twin Survey who were born between 1964 and 1982. Data collected in this study included the mother’s body composition and weight gain during pregnancy, the twins’ birth weights, and gestational age. The twins (aged 18–34 years) attended a research center for measurement of height, weight, and waist-to-hip ratio as well as fasting glucose, proinsulin, and insulin concentrations.
Results: Among twin pairs discordant for birth weight, we found little evidence that the lighter twin had abnormal glucose-insulin metabolism in adult life. However, both a low prepregnancy maternal BMI and older maternal age at delivery were associated with hyperinsulinemia and evidence of insulin resistance in the offspring. Fasting insulin increased by 1.3% (95% CI 0.1–2.6%) per unit fall in maternal BMI and by 1.1% (0.02–2.0%) per year increase in maternal age. These associations were independent of the twins’ BMI and waist-to-hip ratio and their zygosity.
Conclusions: These novel findings suggest that in twin pregnancies, maternal factors are more important than fetoplacental factors in determining glucose-insulin metabolism in the offspring.

PDF 2191.pdf - Version of Record
Restricted to Repository staff only
Download (91kB)

More information

Published date: December 2002

Identifiers

Local EPrints ID: 25769
URI: http://eprints.soton.ac.uk/id/eprint/25769
ISSN: 1935-5548
PURE UUID: ef8c9f68-19c6-4731-8d2a-91ea2e5e78f1

Catalogue record

Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:09

Export record

Altmetrics

Contributors

Author: Ruth J.F. Loos
Author: David I.W. Phillips
Author: Robert Fagard
Author: Gaston Beunen
Author: Catherine Derom
Author: Chantal Mathieu
Author: Johan Verhaeghe
Author: Robert Vlietinck

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×