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Dissociating ocular dominance column development and ocular dominance plasticity: a neurotrophic model

Dissociating ocular dominance column development and ocular dominance plasticity: a neurotrophic model
Dissociating ocular dominance column development and ocular dominance plasticity: a neurotrophic model
Recent experimental data indicate that both neurotrophic factors (NTFs) and intracortical inhibitory circuitry are implicated in the development and plasticity of ocular dominance columns. We extend a neurotrophic model of developmental synaptic plasticity, which previously failed to account correctly for the differences between monocular deprivation and binocular deprivation, and show that the inclusion of lateral cortical inhibition is indeed necessary in understanding the effects of visual deprivation in the model. In particular, we argue that monocular deprivation causes a differential shift in the balance between inhibition and excitation in cortical columns, down-regulating NTFs in deprived-eye columns and up-regulating NTFs in undeprived-eye columns; during binocular deprivation, however, no such shift occurs. We thus postulate that the response to visual deprivation is at the level of the cortical circuit, while the mechanisms of afferent segregation are at the molecular or cellular level. Such a dissociation is supported by recent experimental work challenging the assumption that columnar organisation develops in an activity-dependent, competitive fashion. Our extended model also questions recent attempts to distinguish between heterosynaptic and homosynaptic models of synaptic plasticity.
0340-1200
281-292
Elliott, Terry
b4262f0d-c295-4ea4-b5d8-3931470952f9
Shadbolt, Nigel R
5c5acdf4-ad42-49b6-81fe-e9db58c2caf7
Elliott, Terry
b4262f0d-c295-4ea4-b5d8-3931470952f9
Shadbolt, Nigel R
5c5acdf4-ad42-49b6-81fe-e9db58c2caf7

Elliott, Terry and Shadbolt, Nigel R (2002) Dissociating ocular dominance column development and ocular dominance plasticity: a neurotrophic model. Biological Cybernetics, 86 (4), 281-292.

Record type: Article

Abstract

Recent experimental data indicate that both neurotrophic factors (NTFs) and intracortical inhibitory circuitry are implicated in the development and plasticity of ocular dominance columns. We extend a neurotrophic model of developmental synaptic plasticity, which previously failed to account correctly for the differences between monocular deprivation and binocular deprivation, and show that the inclusion of lateral cortical inhibition is indeed necessary in understanding the effects of visual deprivation in the model. In particular, we argue that monocular deprivation causes a differential shift in the balance between inhibition and excitation in cortical columns, down-regulating NTFs in deprived-eye columns and up-regulating NTFs in undeprived-eye columns; during binocular deprivation, however, no such shift occurs. We thus postulate that the response to visual deprivation is at the level of the cortical circuit, while the mechanisms of afferent segregation are at the molecular or cellular level. Such a dissociation is supported by recent experimental work challenging the assumption that columnar organisation develops in an activity-dependent, competitive fashion. Our extended model also questions recent attempts to distinguish between heterosynaptic and homosynaptic models of synaptic plasticity.

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More information

Published date: March 2002
Organisations: Web & Internet Science

Identifiers

Local EPrints ID: 257872
URI: https://eprints.soton.ac.uk/id/eprint/257872
ISSN: 0340-1200
PURE UUID: b728d785-2bc6-447f-82ef-61340a0772ee

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Date deposited: 26 Jun 2003
Last modified: 27 Feb 2019 17:32

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Contributors

Author: Terry Elliott
Author: Nigel R Shadbolt

University divisions

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