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In silico modeling of asthma

Martonen, Ted, Fleming, John, Schroeter, Jeffrey, Conway, Joy and Hwang, Dongming (2003) In silico modeling of asthma Advanced Drug Delivery Reviews, 55, (7), pp. 829-849. (doi:10.1016/S0169-409X(03)00080-2).

Record type: Article


The incidence of asthma is increasing throughout the world, especially among children, to the extent that it has become a medical issue of serious global concern. Appropriately, numerous pharmacologic drugs and clinical protocols for the treatment and prophylaxis of the disease have been reported. From a scientific perspective, a review of the literature suggests that the targeted delivery of an aerosol would, in a real sense, enhance the efficacy of an inhaled medicine. Therefore, in accordance with published data we have developed a mathematical description of disease-induced effects of disease on airway morphology. A morphological algorithm defining the heterogeneity of asthma has been integrated with a computer code that formulates the behavior and fate of inhaled drugs. In this work, predicted drug particle deposition patterns have been compared with SPECT images from experiments with healthy human subjects (controls) and asthmatic patients. The asthma drug delivery model simulations agree with observations from human testing. The results indicate that in silico modeling provides a technical foundation for addressing effects of disease on the administration of aerosolized drugs, and suggest that modeling should be used in a complementary manner with future inhalation therapy protocols.

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Published date: 1 July 2003
Keywords: targeted drug delivery, particle deposition model, asthma morphology


Local EPrints ID: 25788
ISSN: 0169-409X
PURE UUID: eccab118-cbfb-4f4e-89b6-5e95507a5a4b
ORCID for Joy Conway: ORCID iD

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Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:09

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Author: Ted Martonen
Author: John Fleming
Author: Jeffrey Schroeter
Author: Joy Conway ORCID iD
Author: Dongming Hwang

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