Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats
Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats
Epidemiological studies suggest that poor growth during fetal life and infancy is associated with decreased bone mass in adulthood. However, theses observations have not, to date, been corroborated in animal models. To address this issue we evaluated the influence of maternal protein restriction on bone mass and growth plate morphology among the adult offspring, using a rat model. Maternal protein restriction resulted in a reduction in bone area and BMC, but not BMD, among the offspring in late adulthood. The widened epiphyseal growth plate in the protein-restricted offspring is compatible with the programming of cartilage and bone growth by maternal nutrition in early life.
493-498
Mehta, G.
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Roach, H.I.
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Langley-Evans, S.
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Taylor, P.
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Reading, I.
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Oreffo, R.O.C.
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Aihie-Sayer, A.
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Clarke, N.M.P.
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Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
December 2002
Mehta, G.
aa514b5d-e525-4ffb-b421-3e7376447733
Roach, H.I.
1c0cf1f8-15dc-49a8-aad8-9ed3fd13c05b
Langley-Evans, S.
5dcb50bc-01dc-46fa-a311-f4ecfd85233d
Taylor, P.
28b91e71-fad2-4375-8a1e-535f861901c3
Reading, I.
6f832276-87b7-4a76-a9ed-b4b3df0a3f66
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Aihie-Sayer, A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Clarke, N.M.P.
76688c21-d51e-48fa-a84d-deec66baf8ac
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Mehta, G., Roach, H.I., Langley-Evans, S., Taylor, P., Reading, I., Oreffo, R.O.C., Aihie-Sayer, A., Clarke, N.M.P. and Cooper, C.
(2002)
Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats.
Calcified Tissue International, 71 (6), .
(doi:10.1007/s00223-001-2104-9).
Abstract
Epidemiological studies suggest that poor growth during fetal life and infancy is associated with decreased bone mass in adulthood. However, theses observations have not, to date, been corroborated in animal models. To address this issue we evaluated the influence of maternal protein restriction on bone mass and growth plate morphology among the adult offspring, using a rat model. Maternal protein restriction resulted in a reduction in bone area and BMC, but not BMD, among the offspring in late adulthood. The widened epiphyseal growth plate in the protein-restricted offspring is compatible with the programming of cartilage and bone growth by maternal nutrition in early life.
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Published date: December 2002
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Local EPrints ID: 25803
URI: http://eprints.soton.ac.uk/id/eprint/25803
ISSN: 0171-967X
PURE UUID: da173c65-9456-422f-bcbf-fd5c93fb4ffc
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Date deposited: 19 Apr 2006
Last modified: 18 Mar 2024 02:51
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Author:
G. Mehta
Author:
H.I. Roach
Author:
S. Langley-Evans
Author:
P. Taylor
Author:
I. Reading
Author:
A. Aihie-Sayer
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