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Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats

Mehta, G., Roach, H.I., Langley-Evans, S., Taylor, P., Reading, I., Oreffo, R.O.C., Aihie-Sayer, A., Clarke, N.M.P. and Cooper, C. (2002) Intrauterine exposure to a maternal low protein diet reduces adult bone mass and alters growth plate morphology in rats Calcified Tissue International, 71, (6), pp. 493-498. (doi:10.1007/s00223-001-2104-9).

Record type: Article


Epidemiological studies suggest that poor growth during fetal life and infancy is associated with decreased bone mass in adulthood. However, theses observations have not, to date, been corroborated in animal models. To address this issue we evaluated the influence of maternal protein restriction on bone mass and growth plate morphology among the adult offspring, using a rat model. Maternal protein restriction resulted in a reduction in bone area and BMC, but not BMD, among the offspring in late adulthood. The widened epiphyseal growth plate in the protein-restricted offspring is compatible with the programming of cartilage and bone growth by maternal nutrition in early life.

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Published date: December 2002


Local EPrints ID: 25803
ISSN: 0171-967X
PURE UUID: da173c65-9456-422f-bcbf-fd5c93fb4ffc
ORCID for R.O.C. Oreffo: ORCID iD
ORCID for C. Cooper: ORCID iD

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Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:09

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Author: G. Mehta
Author: H.I. Roach
Author: S. Langley-Evans
Author: P. Taylor
Author: I. Reading
Author: R.O.C. Oreffo ORCID iD
Author: A. Aihie-Sayer
Author: N.M.P. Clarke
Author: C. Cooper ORCID iD

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