The University of Southampton
University of Southampton Institutional Repository

Elastin distribution in the myometrial and vascular smooth muscle of the human uterus

Metaxa-Mariatou, V., McGavigan, C.J., Robertson, K., Stewart, C., Cameron, I.T. and Campbell, S. (2002) Elastin distribution in the myometrial and vascular smooth muscle of the human uterus Molecular Human Reproduction, 8, (6), pp. 559-565. (doi:10.1093/molehr/8.6.559).

Record type: Article


Magnetic resonance imaging and transvaginal ultrasonography in women of reproductive age suggest that the myometrium consists of inner and outer layers. It was hypothesized that these structural and functional differences in the myometrium might be associated with a variation in elastin distribution. Fifty-one hysterectomy specimens representing all phases of the normal menstrual cycle were studied by immunocytochemistry, orcein staining and image analysis. Elastin was present within the outer myometrial smooth muscle, but was less widely distributed in the inner smooth muscle. Immunoreactivity and staining were observed in the myometrial arteries and arterioles and within the basal portions of endometrial arterioles. Elastin was also present in perivascular tissue, particularly near the large vessels. More extravascular (i.e. perivascular and smooth muscle) elastin was present in the outer myometrium in all cases, although no distinct layering was observed. Semi-quantitative analysis of the elastin distribution in 11 full thickness specimens demonstrated a decreasing gradient from outer to inner myometrium rather than distinct layering. Contrary to previous reports, these data suggest that the external region of the myometrium is more elastic than the inner region and that elastin is found throughout the arteriolar tree of the human uterus.

Full text not available from this repository.

More information

Published date: June 2002
Keywords: elastin, image analysis, immunocytochemistry, myometrial gradient, uterus


Local EPrints ID: 25806
ISSN: 1360-9947
PURE UUID: 5edb4015-be38-4e80-8998-0d923fdee50d
ORCID for I.T. Cameron: ORCID iD

Catalogue record

Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:09

Export record



Author: V. Metaxa-Mariatou
Author: C.J. McGavigan
Author: K. Robertson
Author: C. Stewart
Author: I.T. Cameron ORCID iD
Author: S. Campbell

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.