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Elastin distribution in the myometrial and vascular smooth muscle of the human uterus

Metaxa-Mariatou, V., McGavigan, C.J., Robertson, K., Stewart, C., Cameron, I.T. and Campbell, S. (2002) Elastin distribution in the myometrial and vascular smooth muscle of the human uterus Molecular Human Reproduction, 8, (6), pp. 559-565. (doi:10.1093/molehr/8.6.559).

Record type: Article

Abstract

Magnetic resonance imaging and transvaginal ultrasonography in women of reproductive age suggest that the myometrium consists of inner and outer layers. It was hypothesized that these structural and functional differences in the myometrium might be associated with a variation in elastin distribution. Fifty-one hysterectomy specimens representing all phases of the normal menstrual cycle were studied by immunocytochemistry, orcein staining and image analysis. Elastin was present within the outer myometrial smooth muscle, but was less widely distributed in the inner smooth muscle. Immunoreactivity and staining were observed in the myometrial arteries and arterioles and within the basal portions of endometrial arterioles. Elastin was also present in perivascular tissue, particularly near the large vessels. More extravascular (i.e. perivascular and smooth muscle) elastin was present in the outer myometrium in all cases, although no distinct layering was observed. Semi-quantitative analysis of the elastin distribution in 11 full thickness specimens demonstrated a decreasing gradient from outer to inner myometrium rather than distinct layering. Contrary to previous reports, these data suggest that the external region of the myometrium is more elastic than the inner region and that elastin is found throughout the arteriolar tree of the human uterus.

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More information

Published date: June 2002
Keywords: elastin, image analysis, immunocytochemistry, myometrial gradient, uterus

Identifiers

Local EPrints ID: 25806
URI: http://eprints.soton.ac.uk/id/eprint/25806
ISSN: 1360-9947
PURE UUID: 5edb4015-be38-4e80-8998-0d923fdee50d
ORCID for I.T. Cameron: ORCID iD orcid.org/0000-0002-4875-267X

Catalogue record

Date deposited: 19 Apr 2006
Last modified: 17 Jul 2017 16:09

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Contributors

Author: V. Metaxa-Mariatou
Author: C.J. McGavigan
Author: K. Robertson
Author: C. Stewart
Author: I.T. Cameron ORCID iD
Author: S. Campbell

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