Effects of polyphenols on human Th1 and Th2 cytokine production
Effects of polyphenols on human Th1 and Th2 cytokine production
Background
Numerous phenolic compounds are consumed in the diet in a range of foods. There are very few studies of the effects of these compounds on the production of lymphocyte-derived cytokines.
Aim of the study
To investigate the effects of five phenolic compounds on cytokine production by cultured human lymphocytes.
Methods
Human whole blood cultures were stimulated with the T cell stimulant concanavalin A for 48 h in the presence of phenolic compounds (vanillic acid, syringic acid, kaempferol, oleuropein and tyrosol) at concentrations up to 10?4 M. Interleukin (IL)-2, IL-4 and interferon-? (IFN-?) concentrations were measured in the culture supernatants by ELISA.
Results
IFN-? concentration was significantly lower in cultures containing 10?4 M kaempferol than in cultures with kaempferol at 10?7, 10?6and 10?5 M or without kaempferol. The other phenolic compounds did not affect IFN-? concentration and none of the phenolics tested affected IL-2 or IL-4 concentrations.
Conclusions
Some, but not all, phenolic compounds can decrease IFN-? production by stimulated human whole blood cultures.
phenolic compounds, flavonoids, cytokines, lymphocytes
780-784
Miles, E.A.
20332899-ecdb-4214-95bc-922dde36d416
Zoubouli, P.
8ba7c2b5-1ad3-405e-ba44-80e63175c713
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
2005
Miles, E.A.
20332899-ecdb-4214-95bc-922dde36d416
Zoubouli, P.
8ba7c2b5-1ad3-405e-ba44-80e63175c713
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Miles, E.A., Zoubouli, P. and Calder, P.C.
(2005)
Effects of polyphenols on human Th1 and Th2 cytokine production.
Clinical Nutrition, 24 (5), .
(doi:10.1016/j.clnu.2005.04.001).
Abstract
Background
Numerous phenolic compounds are consumed in the diet in a range of foods. There are very few studies of the effects of these compounds on the production of lymphocyte-derived cytokines.
Aim of the study
To investigate the effects of five phenolic compounds on cytokine production by cultured human lymphocytes.
Methods
Human whole blood cultures were stimulated with the T cell stimulant concanavalin A for 48 h in the presence of phenolic compounds (vanillic acid, syringic acid, kaempferol, oleuropein and tyrosol) at concentrations up to 10?4 M. Interleukin (IL)-2, IL-4 and interferon-? (IFN-?) concentrations were measured in the culture supernatants by ELISA.
Results
IFN-? concentration was significantly lower in cultures containing 10?4 M kaempferol than in cultures with kaempferol at 10?7, 10?6and 10?5 M or without kaempferol. The other phenolic compounds did not affect IFN-? concentration and none of the phenolics tested affected IL-2 or IL-4 concentrations.
Conclusions
Some, but not all, phenolic compounds can decrease IFN-? production by stimulated human whole blood cultures.
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More information
Published date: 2005
Keywords:
phenolic compounds, flavonoids, cytokines, lymphocytes
Identifiers
Local EPrints ID: 25815
URI: http://eprints.soton.ac.uk/id/eprint/25815
ISSN: 0261-5614
PURE UUID: f2d56eb0-20be-4abb-9db7-e5f428a89bfe
Catalogue record
Date deposited: 11 Apr 2006
Last modified: 16 Mar 2024 02:51
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Contributors
Author:
P. Zoubouli
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