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Effects of extended-release niacin on lipoprotein subclass distribution

Effects of extended-release niacin on lipoprotein subclass distribution
Effects of extended-release niacin on lipoprotein subclass distribution
The efficacy of extended-release niacin (niacin ER) on lipoprotein subclasses was evaluated in patients with primary hypercholesterolemia using a proton nuclear magnetic resonance method. Paired plasma samples collected at baseline and after 12 weeks’ treatment with niacin ER 1,000 (n = 21) or 2,000 (n = 20) mg/day or placebo (n = 19) were available for 60 eligible patients from a previous multicenter, randomized, controlled trial. Niacin ER increased high-density lipoprotein (HDL) cholesterol and decreased low-density lipoprotein (LDL) cholesterol and very low-density lipoprotein triglycerides in a dose-dependent manner relative to placebo. Niacin ER increased large HDL particles (H5 and H4, corresponding to the HDL2ab fraction) without having a net effect on small HDL particles (H3, H2, and H1, corresponding to the HDL3abc fraction). It also decreased smaller, denser LDL particles (L1 and L2) and increased the larger, more buoyant L3 subclass. The inhibitory effect of niacin ER on very low-density lipoprotein was evident on the larger particles (V6, V5, V4, and V3 subclasses) rather than the smaller ones (V2 and V1). The results show that niacin ER produces a beneficial effect on lipoprotein subclasses, specifically decreasing the more atherogenic small, dense LDL particles and enhancing the cardioprotective large HDL particles.
0002-9149
1432-1436
Morgan, John M.
ac98099e-241d-4551-bc98-709f6dfc8680
Capuzzi, David M.
e6993ee2-2b00-4cab-8fb1-c27ad5f0d799
Baksh, Ronnie I.
7979a1da-299b-48bc-be8b-8bbff00b948f
Intenzo, Charles
d8566107-36e9-4e35-8210-e62e18aed458
Carey, Christina M.
5282c0d2-10af-461e-8000-721cf0efea73
Reese, Dana
937fd205-66d7-479a-964a-ffd946289c15
Walker, Kalen
738faa49-cada-4af9-a156-5337ececd5f2
Morgan, John M.
ac98099e-241d-4551-bc98-709f6dfc8680
Capuzzi, David M.
e6993ee2-2b00-4cab-8fb1-c27ad5f0d799
Baksh, Ronnie I.
7979a1da-299b-48bc-be8b-8bbff00b948f
Intenzo, Charles
d8566107-36e9-4e35-8210-e62e18aed458
Carey, Christina M.
5282c0d2-10af-461e-8000-721cf0efea73
Reese, Dana
937fd205-66d7-479a-964a-ffd946289c15
Walker, Kalen
738faa49-cada-4af9-a156-5337ececd5f2

Morgan, John M., Capuzzi, David M., Baksh, Ronnie I., Intenzo, Charles, Carey, Christina M., Reese, Dana and Walker, Kalen (2003) Effects of extended-release niacin on lipoprotein subclass distribution. The American Journal of Cardiology, 91 (12), 1432-1436. (doi:10.1016/S0002-9149(03)00394-1).

Record type: Article

Abstract

The efficacy of extended-release niacin (niacin ER) on lipoprotein subclasses was evaluated in patients with primary hypercholesterolemia using a proton nuclear magnetic resonance method. Paired plasma samples collected at baseline and after 12 weeks’ treatment with niacin ER 1,000 (n = 21) or 2,000 (n = 20) mg/day or placebo (n = 19) were available for 60 eligible patients from a previous multicenter, randomized, controlled trial. Niacin ER increased high-density lipoprotein (HDL) cholesterol and decreased low-density lipoprotein (LDL) cholesterol and very low-density lipoprotein triglycerides in a dose-dependent manner relative to placebo. Niacin ER increased large HDL particles (H5 and H4, corresponding to the HDL2ab fraction) without having a net effect on small HDL particles (H3, H2, and H1, corresponding to the HDL3abc fraction). It also decreased smaller, denser LDL particles (L1 and L2) and increased the larger, more buoyant L3 subclass. The inhibitory effect of niacin ER on very low-density lipoprotein was evident on the larger particles (V6, V5, V4, and V3 subclasses) rather than the smaller ones (V2 and V1). The results show that niacin ER produces a beneficial effect on lipoprotein subclasses, specifically decreasing the more atherogenic small, dense LDL particles and enhancing the cardioprotective large HDL particles.

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Published date: 2003

Identifiers

Local EPrints ID: 25826
URI: http://eprints.soton.ac.uk/id/eprint/25826
ISSN: 0002-9149
PURE UUID: 9033e3e4-f730-4502-aa12-0b9362ceebc4

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Date deposited: 20 Apr 2006
Last modified: 10 Jul 2024 17:04

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Contributors

Author: John M. Morgan
Author: David M. Capuzzi
Author: Ronnie I. Baksh
Author: Charles Intenzo
Author: Christina M. Carey
Author: Dana Reese
Author: Kalen Walker

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